Pam3CSK4

Pam3CSK4

• CAS Number: 112208-00-1
• UNSPSC Description: Pam3CSK4 is a toll-like receptor 1/2 (TLR1/2) agonist with an EC50 of 0.47 ng/mL for human TLR1/2[1].
• Target Antigen: Toll-like Receptor (TLR)
• Type: Peptides
• Related Pathways: Immunology/Inflammation
• Applications: COVID-19-immunoregulation
• Field of Research: Infection; Inflammation/Immunology
• Assay Protocol: https://www.medchemexpress.com/pam3csk4.html
• Solubility: H2O
• Smiles: CCCCCCCCCCCCCCCC(OCC(OC(CCCCCCCCCCCCCCC)=O)CSC[C@H](NC(CCCCCCCCCCCCCCC)=O)C(N[C@@H](CO)C(N[C@@H](CCCCN)C(N[C@@H](CCCCN)C(N[C@@H](CCCCN)C(N[C@H](C(O)=O)CCCCN)=O)=O)=O)=O)=O)=O
• Molecular Weight: 1510.23
• References & Citations: [1]Irvine KL, et al. The molecular basis for recognition of bacterial ligands at equine TLR2, TLR1 and TLR6. Vet Res. 2013 Jul 4;44:50.|[2]Du X, et al. Systemic stimulation of TLR2 impairs neonatal mouse brain development. PLoS One. 2011 May 6;6(5):e19583.|[3]Chen Y, et al. TLR2 agonist Pam3CSK4 enhances the antibacterial functions of GM-CSF induced neutrophils to methicillin-resistant Staphylococcus aureus. Microb Pathog. 2019 May;130:204-212.Antiviral Res. 2022 May 21;203:105346.|Biochem Biophys Res Commun. 2024 Feb 15, 149661.|Emerg Microbes Infect. 2023 Oct 30:105244.|Int Immunopharmacol. 2022 Feb 15;106:108613.|Mol Immunol. 2021 Feb;130:85-95.|Sci Rep. 2023 Nov 9;13(1):19440.|Chin Herb Med. 2024 Jul.|Int Immunopharmacol. December 2022, 109312.|J Pharm Anal. 2024 Jul 23.|Sci China Life Sci. 2024 Aug 22.|Sci Rep. 2022 Oct 12;12(1):17058.
• Shipping Conditions: Room temperature
• Clinical Information: No Development Reported