Pam3CSK4

• Description :

  Formula : C81H156N10O13S.3HCl MW: 1510.3 . 109.4 Selective agonist of TLR1/TLR2 complex. Cell permeable, water soluble synthetic cationic lipohexapeptide analog of the immunologically active N-terminal portion of bacterial lipoprotein that potently activates monocytes and macrophages. Potent and effective immune adjuvant. Exerts strong local response, enhances IgG2a and IgG1 titers and upregulates proinflammatory and Th1 cytokine genes. Potent activator of the proinflammatory transcription factor NF-κB.

• Product Name Alternative :

  Pam3CSK4; Pam3Cys-SKKKK; (S) -[2,3-Bis (palmitoyloxy) - (2- RS) -propyl]-N-palmitoyl- (R) -Cys- (S) -Ser- (S) -Lys4-OH

• Applications :

  Functional Assay

• Components :

  (1mg/ml) in Sterile Water

• Storage Conditions :

  Store the product at 4°C for short term and at -20°C for long-term storage. Product is stable for 2 years at -20°C.

• Applications Notes :

  Purity: Absence of detectable protein or DNA contaminants with agonistic TLR activity. Solubility: Soluble in water, saline or aqueous buffers at pH <7.5.