Gly-Arg-Gly-Asp-Ser (TFA)

Gly-Arg-Gly-Asp-Ser (TFA)

• CAS Number: 2828433-23-2
• UNSPSC Description: Gly-Arg-Gly-Asp-Ser (TFA) is a pentapeptide that forms the cell-binding domain of a glycoprotein, osteopontin[1]. Gly-Arg-Gly-Asp-Ser binds to integrin receptors αvβ3 and αvβ5 with estimated IC50 of ∼5 and ∼6.5 μM[2].
• Target Antigen: Integrin
• Type: Peptides
• Related Pathways: Cytoskeleton
• Applications: COVID-19-immunoregulation
• Field of Research: Inflammation/Immunology
• Assay Protocol: https://www.medchemexpress.com/gly-arg-gly-asp-ser-tfa.html
• Solubility: H2O
• Smiles: O=C(N[C@@H](CCCNC(N)=N)C(NCC(N[C@@H](CC(O)=O)C(N[C@@H](CO)C(O)=O)=O)=O)=O)CN.OC(C(F)(F)F)=O
• Molecular Weight: 604.49
• References & Citations: [1]Kim GH, et al. Evaluation of Osteoblast-Like Cell Viability and Differentiation on the Gly-Arg-Gly-Asp-Ser Peptide Immobilized Titanium Dioxide Nanotube via Chemical Grafting. J Nanosci Nanotechnol. 2016 Feb;16(2):1396-9.|[2]Bernhagen D, et al. High-Affinity RGD-Knottin Peptide as a New Tool for Rapid Evaluation of the Binding Strength of Unlabeled RGD-Peptides to αvβ3, αvβ5, and α5β1 Integrin Receptors. Anal Chem. 2017 Jun 6;89(11):5991-5997.
• Shipping Conditions: Room temperature
• Clinical Information: No Development Reported