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Cyclopeptide-5

CAT: 0804-HY-A0300Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-A0300Size:1 Each
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Cyclopeptide-5 (EMD 270179) is an αvβ3 antagonist that can improve PAF-induced increased adhesion of sickle red blood cells, capillary post-obstruction, and enhance blood flow dynamics. Cyclopeptide-5 also has cytotoxic effects[1][2].
CAS Number
197172-76-2
Product Name Alternative
EMD 270179
UNSPSC
12352209
Hazard Statement
H302-H315-H319-H335
Target
Integrin
Type
Reference compound
Related Pathways
Cytoskeleton
Applications
Neuroscience-Neuromodulation
Field of Research
Cardiovascular Disease
Assay Protocol
https://www.medchemexpress.com/cyclopeptide-5.html
Smiles
O=C1C2(CCCCC2)NC([C@H](NC([C@@H](NC(CNC([C@@H](N1)CCCNC(N)=N)=O)=O)CC(O)=O)=O)CC3=CC=CC=C3)=O
Molecular Formula
C28H40N8O7
Molecular Weight
600.67
Precautions
P261-P280-P302+P352
References & Citations
[1]M Abo-Ghalia, et al. Synthesis and investigation of a new cyclo (Nalpha-dipicolinoyl) pentapeptide of a breast and CNS cytotoxic activity and an ionophoric specificity. Amino Acids. 2004 Jun;26 (3) :283-9.|[2]Eileen M Finnegan, et al. Small-molecule cyclic alpha V beta 3 antagonists inhibit sickle red cell adhesion to vascular endothelium and vasoocclusion. Am J Physiol Heart Circ Physiol. 2007 Aug;293 (2) :H1038-45.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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