Melperone (Standard)

CAT: 0804-HY-B2169RSize: 1 EachDry Ice: NoHazardous: No
CAT#:0804-HY-B2169RSize:1 Each
Selected
PRICE
AVAILABILITY: InStock
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Product image 1
1 / 1
Description
Melperone (Standard) is the analytical standard of Melperone (HY-B2169) . This product is intended for research and analytical applications. Melperone is a butyrophenone with atypical antipsychotic properties. Melperone is a multireceptor antagonist with Kds of 102 nM, 180 nM, 180 nM, and 150 nM for 5-HT2A, dopamine D2, α1-adrenergic, and α2-adrenergic receptors, respectively. Melperone has weak binding to histamine H1, 5-HT2C, 5-HT1A, 5-HT1D, and muscarinic receptors, with Kd values ​​of 580 nM, 2100 nM, 2200 nM, 3400 nM, >10000 nM, respectively. Melperone is also a CYP2D6 inhibitor. Melperone can be used for the study of schizophrenia, and agitation in the elderly.
CAS Number
[3575-80-2]
UNSPSC
12352005
Target
5-HT Receptor; Adrenergic Receptor; Cytochrome P450; Dopamine Receptor; Reference Standards
Type
Reference Standards
Related Pathways
GPCR/G Protein; Metabolic Enzyme/Protease; Neuronal Signaling; Others
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/melperone-standard.html
Smiles
O=C(C1=CC=C(F)C=C1)CCCN2CCC(C)CC2
Molecular Formula
C16H22FNO
Molecular Weight
263.35
References & Citations
[1]Hefner G, et al. Melperone but not bisoprolol or metoprolol is a clinically relevant inhibitor of CYP2D6: evidence from a therapeutic drug monitoring survey. J Neural Transm (Vienna) . 2015 Nov;122 (11) :1609-17.|[2]Bobo WV, et al. Melperone, an aytpical antipsychotic drug with clozapine-like effect on plasma prolactin: contrast with typical neuroleptics. Hum Psychopharmacol. 2009 Jul;24 (5) :415-22.
Shipping Conditions
Room temperature
Scientific Category
Reference Standards
Isoform
5-HT1 Receptor;5-HT2 Receptor; CYP2D6; D2 Receptor; α adrenergic receptor

Related Products

CatalogName
HY-B2169-01Melperone
HY-103109-01Melperone (hydrochloride)
HY-B2169S2-01Melperone-d4 (hydrochloride)
HY-W099580R-01Hexadecane (Standard)
HY-W050088R-01Isoxepac (Standard)
HY-N0540R-01Cynaroside (Standard)
HY-115584R-01Lufenuron (Standard)
HY-B0511R-01Biotin (Standard)
HY-13683R-01Mifepristone (Standard)
HY-N0322R-01Cholesterol (Standard)

Alternative Products

CatalogName
MBS5752536Melperone
B7078-10Melperone hydrochloride
sc-488944AMelperone-d4
TRC-M216802-25MGMelperone Hydrochloride-d4
MF-0101724-01Melperone-d4 hydrochloride
M216803Melperone HydrochlorideDisontinued. Please offer M216800.
M216804Melperone-d4 HCl (4-methylpiperidine-2,2,6,6-d4)
abx092106Standard

Popular Products