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LRRK2-IN-1

CAT: 0026-B2940-1Size: 1 mgDry Ice: NoHazardous: No
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CAT#:0026-B2940-1Size:1 mg
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Description
LRRK2-IN-1 is a potent inhibitor of Leucine-rich repeat kinase 2 (LRRK2). Mutations in LRRK2 are associated with Parkinson's disease. LRRK2-IN-1 inhibits wild-type and G2019S mutant LRRK2 with IC₅₀ values of 13 nM and 6 nM, respectively. It suppresses LRRK2 kinase activity in vivo leading to dephosphorylation of Ser910/Ser935, loss of 14-3-3 binding and accumulation of LRRK2 within aggregate structures. It stimulates autophagy in H4 neuroglioma cells.
Shipping Conditions
RT
Storage Conditions
-20ºC
Shelf Life
36 months

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T2246-01LRRK2-IN-1

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