Akuammine

• Description :

  Akuammine is an indole alkaloid that has been found in Picralima nitida and has analgesic activity. It selectively binds to the μ- and κ-opioid receptors over the δ-opioid receptor (Kis=0.3, 1.68, and 10.4 μM for the human receptors, respectively) . Akuammine inhibits forskolin-induced cAMP production in HEK293 cells expressing human μ- or κ-opioid receptors (IC50s=2.6 and 0.073 μM, respectively) . It increases the latency to withdrawal in the tail-flick or hot plate test in mice when administered at a dose of 60 mg/kg.

• CAS Number :

  [3512-87-6]

• Product Name Alternative :

  (-) -Akuammine; Vincamajoridine

• UNSPSC :

  12352005

• Target :

  Others

• Type :

  Reference compound

• Related Pathways :

  Others

• Applications :

  Neuroscience-Neuromodulation

• Field of Research :

  Neurological Disease

• Assay Protocol :

  https://www.medchemexpress.com/akuammine.html

• Smiles :

  COC([C@]12C34[C@]([C@]5([H])CC2/C(CN5CC3)=C\C)(N(C)C6=C4C=C(O)C=C6)OC1)=O

• Molecular Formula :

  C22H26N2O4

• Molecular Weight :

  382.45

• References & Citations :

  [1]Creed, et al. Isolation and pharmacological characterization of six opioidergic Picralima nitida alkaloids. J. Nat. Prod. 84 (1), 71-80 (2021) .

• Shipping Conditions :

  Room temperature

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported