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Akuammine

CAT: 0804-HY-122189-01Size: 1 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-122189-01Size:1 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Akuammine is an indole alkaloid that has been found in Picralima nitida and has analgesic activity. It selectively binds to the μ- and κ-opioid receptors over the δ-opioid receptor (Kis=0.3, 1.68, and 10.4 μM for the human receptors, respectively) . Akuammine inhibits forskolin-induced cAMP production in HEK293 cells expressing human μ- or κ-opioid receptors (IC50s=2.6 and 0.073 μM, respectively) . It increases the latency to withdrawal in the tail-flick or hot plate test in mice when administered at a dose of 60 mg/kg.
CAS Number
3512-87-6
Product Name Alternative
(-) -Akuammine; Vincamajoridine
UNSPSC
12352005
Target
Others
Type
Reference compound
Related Pathways
Others
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/akuammine.html
Smiles
COC([C@]12C34[C@]([C@]5([H])CC2/C(CN5CC3)=C\C)(N(C)C6=C4C=C(O)C=C6)OC1)=O
Molecular Formula
C22H26N2O4
Molecular Weight
382.45
References & Citations
[1]Creed, et al. Isolation and pharmacological characterization of six opioidergic Picralima nitida alkaloids. J. Nat. Prod. 84 (1), 71-80 (2021) .
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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