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Akuammidine

CAT: 0804-HY-N7437-01Size: 10 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-N7437-01Size:10 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Akuammidine, isolated from the seeds of Picralima nitida, shows a preference for μ-opioid binding sites with Ki values of 0.6, 2.4 and 8.6 μM at μ-, σ- and κ-opioid binding sites, respectively. Akuammidine possesses anti-inflammatory and anti-asthmatic properties[1][2].
CAS Number
639-36-1
UNSPSC
12352005
Target
DNA/RNA Synthesis; Opioid Receptor
Type
Natural Products
Related Pathways
Cell Cycle/DNA Damage; GPCR/G Protein; Neuronal Signaling
Applications
COVID-19-anti-virus
Field of Research
Inflammation/Immunology; Neurological Disease
Assay Protocol
https://www.medchemexpress.com/akuammidine.html
Solubility
10 mM in DMSO
Smiles
O=C([C@@]1([C@@](CC2=C3NC4=CC=CC=C24)([H])[N@@](C/5)[C@H]3C[C@H]1C5=C/C)CO)OC
Molecular Formula
C21H24N2O3
Molecular Weight
352.43
References & Citations
[1]Yuanyuan Hou, et al. Microfractionation Bioactivity-Based Ultra Performance Liquid Chromatography/Quadrupole Time-Of-Flight Mass Spectrometry for the Identification of Nuclear factor-κB Inhibitors and β2 Adrenergic Receptor Agonists in an Alkaloidal Extract of the Folk Herb Alstonia Scholaris. J Chromatogr B Analyt Technol Biomed Life Sci. 2012 Nov 1;908:98-104.|[2]J R Menzies, et al. Opioid Activity of Alkaloids Extracted From Picralima Nitida (Fam. Apocynaceae) . Eur J Pharmacol. 1998 May 29;350 (1) :101-8.
Shipping Conditions
Room temperature
Scientific Category
Natural Products
Clinical Information
No Development Reported
Isoform
κ Opioid Receptor/KOR

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