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Daunomycinone

CAT: 0804-HY-114658-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-114658-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Daunomycinone (NSC-109351) is a metabolite of Daunomycin and anticancer intermediate. Daunomycinone binds to nucleic acids synergistically with metal ions. Daunomycinone can be used in the research of leukemia[1][2][3][4][5].
CAS Number
21794-55-8
Product Name Alternative
NSC-109351
UNSPSC
12352005
Hazard Statement
H301, H315, H317, H319, H334, H335, H340, H351, H360
Target
Drug Intermediate; Drug Metabolite
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease; Others
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/daunomycinone.html
Purity
98.89
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
O=C(C1=CC=CC(OC)=C1C2=O)C3=C2C(O)=C4[C@H](C[C@](C(C)=O)(CC4=C3O)O)O
Molecular Formula
C21H18O8
Molecular Weight
398.36
Precautions
H301, H315, H317, H319, H334, H335, H340, H351, H360
References & Citations
[1]Herman EH, et al. Modification of some of the toxic effects of daunomycin (NSC-82,151) by pretreatment with the antineoplastic agent ICRF 159 (NSC-129,943) . Toxicol Appl Pharmacol. 1974 Mar;27 (3) :517-26.|[2]Tan C, et al. Daunomycin, an antitumor antibiotic, in the treatment of neoplastic disease. Clinical evaluation with special reference to childhood leukemia. Cancer. 1967 Mar;20 (3) :333-53.|[3]Baer H H, et al. Synthesis and biological activity of (S) -2′-fluorodaunorubicin. Canadian journal of chemistry, 1988, 66 (1) : 187-190.|[4]Aligiannis N, et al. Synthesis and cytotoxic activity of a new potent daunomycinone derivative. Bioorg Med Chem Lett. 2002 Dec 16;12 (24) :3505-7.|[5]Mikelens P, et al. Metal ion participation in binding of daunomycinone, daunomycin, and adriamycin to nucleic acids. Bioinorganic Chemistry, 1978, 9 (5) : 441-452.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C (Powder, protect from light)
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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