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AKP-001

CAT: 0804-HY-100278-01Size: 1 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-100278-01Size:1 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
AKP-001 is an inhibitor of p38 mitogen-activated protein kinase (p38 MAPK) . AKP-001 can inhibit the production of inflammatory cytokines and can be used for research in rheumatoid arthritis and inflammatory bowel disease[1].
CAS Number
897644-83-6
UNSPSC
12352005
Target
P38 MAPK
Type
Reference compound
Related Pathways
MAPK/ERK Pathway
Field of Research
Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/akp-001.html
Smiles
O=C(NC1=C(C2=NC=NC=C2)C(C3=CC=C(F)C=C3)=NO1)CC4=C(F)C=CC=C4Cl
Molecular Formula
C21H13ClF2N4O2
Molecular Weight
426.80
References & Citations
[1]Hasumi K, et al. Design and synthesis of 5-[ (2-chloro-6-fluorophenyl) acetylamino]-3- (4-fluorophenyl) -4- (4-pyrimidinyl) isoxazole (AKP-001), a novel inhibitor of p38 MAP kinase with reduced side effects based on the antedrug concept. Bioorg Med Chem. 2014 Aug 1;22 (15) :4162-76.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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