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COR628

CAT: 0804-HY-123525Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-123525Size:1 Each
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Description
COR628 is a positive allosteric modulator of GABA (B) receptors with the activity of enhancing GABA-induced GTPγS stimulation. COR628 showed significant activity in in vitro studies but did not exhibit endogenous agonist activity. COR628 has shown efficacy in experiments in mice by enhancing the sedation/hypnosis induced by baclofen, shortening the onset time and extending the duration of loss of righting reflex when combined with non-sedating doses of baclofen . The cytotoxic effect of COR628 is comparable to or higher than that of GS39783 or BHF177 in concentration[1].
CAS Number
550310-04-8
UNSPSC
12352005
Target
GABA Receptor
Type
Reference compound
Related Pathways
Membrane Transporter/Ion Channel; Neuronal Signaling
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/cor628.html
Smiles
O=C(OC)C1=C(SC(C)=C1CC)NC(C2CCCCC2)=O
Molecular Formula
C16H23NO3S
Molecular Weight
309.42
References & Citations
[1]Synthesis and pharmacological characterization of 2- (acylamino) thiophene derivatives as metabolically stable, orally effective, positive allosteric modulators of the GABAB receptor
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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