hCA/VEGFR-2-IN-5

• UNSPSC Description:

  hCA/VEGFR-2 IN-5 (compound 9) is an indolone-phenylsulfonamide and a potential dual inhibitor of cancer-related hCA IX/XII and VEGFR-2. The IC50 values of hCA/VEGFR-2-IN-5 for VEGFR-2, hCA IX and hCA XII are 0.38 μM, 40 and 3.2 nM, respectively. hCA/VEGFR-2-IN-5 has antitumor activity[1].

• Target Antigen:

  Carbonic Anhydrase; VEGFR

• Type:

  Reference compound

• Related Pathways:

  Metabolic Enzyme/Protease;Protein Tyrosine Kinase/RTK

• Applications:

  Cancer-Kinase/protease

• Field of Research:

  Cancer

• Assay Protocol:

  https://www.medchemexpress.com/hca-vegfr-2-in-5.html

• Smiles:

  O=S(C1=CC=C(N2N=NC(CO[C@H]3[C@@H]([C@H]([C@@H](CO3)OC(C)=O)OC(C)=O)OC(C)=O)=C2)C=C1)(NC4CCCCC4)=O

• Molecular Weight:

  594.63

• References & Citations:

  [1]Abbas HS, et al. New sulfonamide-based glycosides incorporated 1,2,3-triazole as cytotoxic agents through VEGFR-2 and carbonic anhydrase inhibitory activity. Sci Rep. 2024 Jun 6;14(1):13028.

• Shipping Conditions:

  Room temperature

• Clinical Information:

  No Development Reported