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Chromogranin A (PHE5), 0.2mg/mL

CAT: 0037-BNUB0461-500Size: 1x 500 µLDry Ice: NoHazardous: No
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CAT#:0037-BNUB0461-500Size:1x 500 µL
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Description
Chromogranin A is present in neuroendocrine cells throughout the body, including the neuroendocrine cells of the large and small intestine, adrenal medulla and pancreatic islets. It is an excellent marker for carcinoid tumors, pheochromocytomas, paragangliomas, and other neuroendocrine tumors. Co-expression of chromogranin A and neuron specific enolase (NSE) is common in neuroendocrine neoplasms. Reportedly, co-expression of certain keratins and chromogranin indicates neuroendocrine lineage. The presence of strong anti-chromogranin staining and absence of anti-keratin staining should raise the possibility of paraganglioma. The co-expression of chromogranin and NSE is typical of neuroendocrine neoplasms. Most pituitary adenomas and prolactinomas readily express chromogranin.Primary antibodies are available purified, or with a selection of fluorescent CF® Dyes and other labels. CF® Dyes offer exceptional brightness and photostability. Note: Conjugates of blue fluorescent dyes like CF®405S and CF®405M are not recommended for detecting low abundance targets, because blue dyes have lower fluorescence and can give higher non-specific background than other dye colors.
CAS Number
9007-83-4
Synonyms
Beta-Granin; CGA; CHGA; Chromogranin A Parathyroid Secretory Protein 1; ER-37; Pancreastatin; Parastatin; Pituitary Secretory Protein I; SP-I; Vasostatin I or II
UNSPSC
41116161
UNSPSC Description
Primary and secondary antibodies for multiple methodology immunostaining detection application
Gene Name
CHGA
Gene ID
1113
NCBI Gene ID
150793
UniProt
P10645
Swiss Prot
P10645
Host
Mouse
Species Reactivity
Human, Monkey
Reactivity
CHGA|Chromogranin A
Immunogen
Human pheochromocytoma
Target Antigen
CHGA | Chromogranin A
Clonality
Monoclonal
Clone
PHE5
Type
Primary
Source
Animal
Origin
Animal
Applications
IHC, FFPE (verified)
Field of Research
Cancer, Endocrinology
Positive Control
PC12 cells. Adrenal gland, bowel, thyroid, pancreas, or pheochromocytoma.
Stability
2 years
Concentration
0.2 mg/mL
Buffer
PBS, 0.05% BSA, 0.05% azide
Molecular Weight
68-75 kDa
Shipping Conditions
RT (ND)
Storage Conditions
Stable at room temperature or 37°C (98°F) for 7 days.
Shelf Life
Guaranteed for at least 24 months from date of receipt when stored as recommended
Fragment
IgG1, kappa
Species
Mus musculus (mouse), BSA from bovine serum (Bos taurus) or recombinant BSA produced in Chinese hamster ovary cells.
Classification
PBS, 0.05% BSA, 0.05% sodium azide (CAS 26628-22-8)
Conjugate
Purified, with BSA

UniProtKB · P10645

Chromogranin-A

CMGA_HUMAN · Homo sapiens

View on UniProt ↗
Primary accession
P10645
Review status
UniProtKB reviewed (Swiss-Prot)
Gene
CHGA
Protein existence
1: Evidence at protein level
Organism
Homo sapiens (Human)
Taxonomy ID
9606
Alternative names
CgA
EC number
—
Processing
Precursor
Secondary accessions
B2R9E9, Q53FA8, Q6NR84, Q96E84, Q96GL7, Q9BQB5
Protein keywords

Technical term

3D-structureDirect protein sequencingProteomics identificationReference proteome

PTM

AmidationCleavage on pair of basic residuesDisulfide bondGlycoproteinOxidationPhosphoproteinProteoglycanSulfation

Molecular function

AntibioticAntimicrobialFungicide

Ligand

Calcium

Cellular component

Cytoplasmic vesicleSecreted

Domain

Signal
Product Datasheet
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