Artemether

CAT: 0804-HY-N0402-01Size: 100 mgDry Ice: NoHazardous: No

1 / 1

CAT#:0804-HY-N0402-01Size:100 mg

Selected

24/48H Stock Items & 2 to 6 Weeks non Stock Items.

Quick Request Actions

Description

Artemether is an anti-malarial compound that targets drug-resistant strains of falciparum malaria[1].

CAS Number

71963-77-4

Product Name Alternative

Dihydroqinghaosu methyl ether; Dihydroartemisinin methyl ether; SM224

UNSPSC

12352005

Hazard Statement

H302

Target

Parasite

Type

Natural Products

Related Pathways

Anti-infection

Applications

COVID-19-immunoregulation

Field of Research

Cancer; Infection; Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/artemether.html

Purity

99.20

Solubility

DMSO : 100 mg/mL (ultrasonic) |H2O : < 0.1 mg/mL

Smiles

C[C@H]1[C@@H](OC)O[C@@]2([H])[C@]34[C@@]([C@H](C)CC[C@]41[H])([H])CC[C@@](O2)(C)OO3

Molecular Formula

C16H26O5

Molecular Weight

298.37

Precautions

H302

References & Citations

[1]Xiao, S., et al., Recent investigations of artemether, a novel agent for the prevention of schistosomiasis japonica, mansoni and haematobia. Acta Trop, 2002. 82 (2) : p. 175-81.|[2]Wu, Z.P., et al., Inhibitive effect of artemether on tumor growth and angiogenesis in the rat C6 orthotopic brain gliomas model. Integr Cancer Ther, 2009. 8 (1) : p. 88-92.|[3]Wu H, et al. Artemether attenuates LPS-induced inflammatory bone loss by inhibiting osteoclastogenesis and bone resorption via suppression of MAPK signaling pathway. Cell Death Dis. 2018 May 1;9 (5) :498. |[4]Wang JX, et al. Investigation of the immunosuppressive activity of artemether on T-cell activation and proliferation. Br J Pharmacol. 2007 Mar;150 (5) :652-61.

Shipping Conditions

Room Temperature

Storage Conditions

-20°C, 3 years; 4°C, 2 years (Powder)

Scientific Category

Natural Products

Clinical Information

Launched

Isoform

Plasmodium

Chemical Information

Artemether

Artemether is an artemisinin derivative that is artemisinin in which the lactone has been converted to the corresponding lactol methyl ether. It is used in combination with lumefantrine as an antimalarial for the treatment of multi-drug resistant strains of falciparum malaria. It has a role as an antimalarial. It is an organic peroxide, a sesquiterpenoid, a cyclic acetal, an artemisinin derivative and a semisynthetic derivative.

CAS Number	71963-77-4
PubChem CID	68911
IUPAC Name	(1R,4S,5R,8S,9R,10S,12R,13R)-10-methoxy-1,5,9-trimethyl-11,14,15,16-tetraoxatetracyclo[10.3.1.04,13.08,13]hexadecane
Molecular Formula	C16H26O5
Molecular Weight	298.37
XLogP	3.1
Topological Polar Surface Area	46.2
Hydrogen Bond Donor Count	0
Hydrogen Bond Acceptor Count	5
Rotatable Bond Count	1
Heavy Atom Count	21
Formal Charge	0
Complexity	429

SMILES

C[C@@H]1CC[C@H]2[C@H]([C@H](O[C@H]3[C@@]24[C@H]1CC[C@](O3)(OO4)C)OC)C

InChI

InChI=1S/C16H26O5/c1-9-5-6-12-10(2)13(17-4)18-14-16(12)11(9)7-8-15(3,19-14)20-21-16/h9-14H,5-8H2,1-4H3/t9-,10-,11+,12+,13+,14-,15-,16-/m1/s1

InChIKey

SXYIRMFQILZOAM-HVNFFKDJSA-N

Chemical Structure

2D Structure

CAS: 71963-77-4

CID: 68911

Formula: C16H26O5

MW: 298.37

Interactive 3D Structure

Loading 3D structure...

View on PubChem Raw 3D data

Computed Properties

Property	Value
Molecular Weight	298.37
XLogP3	3.1
Hydrogen Bond Donor Count	0
Hydrogen Bond Acceptor Count	5
Rotatable Bond Count	1
Exact Mass	298.17802393
Monoisotopic Mass	298.17802393
Topological Polar Surface Area	46.2 Å²
Heavy Atom Count	21
Formal Charge	0
Complexity	429
Isotope Atom Count	0
Defined Atom Stereocenter Count	8
Undefined Atom Stereocenter Count	0
Defined Bond Stereocenter Count	0
Undefined Bond Stereocenter Count	0
Covalently-Bonded Unit Count	1
Compound Is Canonicalized	Yes

Alternative Products

Catalog	Name
T1323-01	Artemether
sc-396232	α-Artemether
FA17992-01	A-Artemether

Artemether

Chemical Information

Alternative Products

Popular Products