Artemether

• Description:

  Artemether is an anti-malarial compound that targets drug-resistant strains of falciparum malaria[1].

• Product Name Alternative:

  Dihydroqinghaosu methyl ether; Dihydroartemisinin methyl ether; SM224

• UNSPSC:

  12352005

• Hazard Statement:

  H302

• Target:

  Parasite

• Type:

  Natural Products

• Related Pathways:

  Anti-infection

• Applications:

  COVID-19-immunoregulation

• Field of Research:

  Cancer; Infection; Inflammation/Immunology

• Assay Protocol:

  https://www.medchemexpress.com/artemether.html

• Purity:

  99.20

• Solubility:

  DMSO : 100 mg/mL (ultrasonic) |H2O : < 0.1 mg/mL

• Smiles:

  C[C@H]1[C@@H](OC)O[C@@]2([H])[C@]34[C@@]([C@H](C)CC[C@]41[H])([H])CC[C@@](O2)(C)OO3

• Molecular Formula:

  C16H26O5

• Molecular Weight:

  298.37

• Precautions:

  H302

• References & Citations:

  [1]Xiao, S., et al., Recent investigations of artemether, a novel agent for the prevention of schistosomiasis japonica, mansoni and haematobia. Acta Trop, 2002. 82 (2) : p. 175-81.|[2]Wu, Z.P., et al., Inhibitive effect of artemether on tumor growth and angiogenesis in the rat C6 orthotopic brain gliomas model. Integr Cancer Ther, 2009. 8 (1) : p. 88-92.|[3]Wu H, et al. Artemether attenuates LPS-induced inflammatory bone loss by inhibiting osteoclastogenesis and bone resorption via suppression of MAPK signaling pathway. Cell Death Dis. 2018 May 1;9 (5) :498. |[4]Wang JX, et al. Investigation of the immunosuppressive activity of artemether on T-cell activation and proliferation. Br J Pharmacol. 2007 Mar;150 (5) :652-61.

• Shipping Conditions:

  Room Temperature

• Storage Conditions:

  -20°C, 3 years; 4°C, 2 years (Powder)

• Scientific Category:

  Natural Products

• Clinical Information:

  Launched

• Isoform:

  Plasmodium

• CAS Number:

  [71963-77-4]