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Norvancomycin (monohydrochloride)

CAT: 0804-HY-B1924-01Size: 1 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-B1924-01Size:1 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Norvancomycin hydrochloride is a cell wall synthesis inhibitor targeting peptidoglycan precursors of Gram-positive bacteria and cannot pass the blood-brain barrier. Norvancomycin hydrochloride can competitively bind to peptidoglycan precursors, irreversibly inhibit bacterial cell wall synthesis, and exert antibacterial activity. Norvancomycin hydrochloride is mainly used in the study of Gram-positive bacterial infections, especially infections caused by methicillin-resistant Staphylococcus aureus (MRSA) and methicillin-resistant Staphylococcus epidermidis (MRSE) . Norvancomycin hydrochloride can also be incorporated into the bionic calcium phosphate coating of titanium implants to enhance antibacterial activity and inhibit postoperative orthopedic infections[1][2].
CAS Number
213997-73-0
Product Name Alternative
N-Demethylvancomycin (monohydrochloride) ; NVCM (monohydrochloride)
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
Antibiotic; Bacterial
Type
Reference compound
Related Pathways
Anti-infection
Applications
COVID-19-immunoregulation
Field of Research
Infection
Assay Protocol
https://www.medchemexpress.com/Norvancomycin-hydrochloride.html
Purity
96.79
Solubility
DMSO : ≥ 100 mg/mL|H2O : ≥ 100 mg/mL
Smiles
O[C@@H]1[C@@H](O[C@@](O[C@@H](C)[C@H]2O)([H])C[C@@]2(N)C)[C@@H](O[C@H](CO)[C@H]1O)OC3=C(OC4=CC=C([C@H]([C@H]5NC([C@H](N)CC(C)C)=O)O)C=C4Cl)C=C([C@](NC([C@@H](NC5=O)CC(N)=O)=O)([H])C(N[C@](C6=O)([H])C7=CC8=C(O)C=C7)=O)C=C3OC9=CC=C([C@H]([C@](C(N[C@@](C(O)=O)([H])C%10=C8C(O)=CC(O)=C%10)=O)([H])N6)O)C=C9Cl.Cl
Molecular Formula
C65H74Cl3N9O24
Molecular Weight
1471.69
Precautions
H302, H315, H319, H335
References & Citations
[1]Zhou T, et al. Study on pharmacokinetics and tissue distribution of norvancomycin in rats by CE with electrochemical detection. Electrophoresis. 2006 May;27 (9) :1790-6.|[2]Pan CJ, et al. Enhancing the antibacterial activity of biomimetic HA coatings by incorporation of norvancomycin. J Orthop Sci. 2011 Jan;16 (1) :105-13.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, sealed storage, away from moisture)
Scientific Category
Reference compound1
Clinical Information
Launched
Isoform
Glycopeptide

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