CD7 (C7/511), 0.2mg/mL

• Description:

  Recognizes a protein of 40 kDa, identified as CD7, a member of the immunoglobulin gene superfamily. Its N-terminal amino acids 1-107 are highly homologous to Ig kappa-L chains whereas the carboxyl-terminal region of the extracellular domain is proline-rich and has been postulated to form a stalk from which the Ig domain projects. CD7 is expressed on the majority of immature and mature T-lymphocytes, and T cell leukemia. It is also found on natural killer cells, a small subpopulation of normal B cells and on malignant B cells. Cross-linking surface CD7 positively modulates T cell and NK cell activity as measured by calcium fluxes, expression of adhesion molecules, cytokine secretion and proliferation. CD7 associates directly with phosphoinositol 3'-kinase. CD7 ligation induces production of D-3 phosphoinositides and tyrosine phosphorylation.Primary antibodies are available purified, or with a selection of fluorescent CF® Dyes and other labels. CF® Dyes offer exceptional brightness and photostability. Note: Conjugates of blue fluorescent dyes like CF®405S and CF®405M are not recommended for detecting low abundance targets, because blue dyes have lower fluorescence and can give higher non-specific background than other dye colors.

• Synonyms:

  GP40; Leu9; p41; T-cell leukemia antigen; T-cell surface antigen Leu-9; Tp40; TP41

• UNSPSC:

  41116161

• UNSPSC Description:

  Primary and secondary antibodies for multiple methodology immunostaining detection application

• Gene Name:

  CD7

• Gene ID:

  924

• NCBI Gene ID:

  186820

• UniProt:

  P09564

• Swiss Prot:

  P09564

• Host:

  Mouse

• Species Reactivity:

  Human

• Reactivity:

  CD7

• Immunogen:

  Recombinant human CD7 protein

• Target Antigen:

  CD7

• Clonality:

  Monoclonal

• Clone:

  C7/511

• Type:

  Primary

• Source:

  Animal

• Origin:

  Animal

• Field of Research:

  Immunology, Signal transduction

• Positive Control:

  Jurkat, HUT-78, Molt-4, CEM cells, or human peripheral blood lymphocytes. Lymph node and tonsil.

• Stability:

  2 years

• Concentration:

  0.2 mg/mL

• Buffer:

  PBS, 0.05% BSA, 0.05% azide

• Molecular Weight:

  40 kDa

• Shipping Conditions:

  RT (ND)

• Storage Conditions:

  Stable at room temperature or 37°C (98°F) for 7 days.

• Shelf Life:

  Guaranteed for at least 24 months from date of receipt when stored as recommended

• Fragment:

  IgG2a

• Species:

  Mus musculus (mouse), BSA from bovine serum (Bos taurus) or recombinant BSA produced in Chinese hamster ovary cells.

• Classification:

  PBS, 0.05% BSA, 0.05% sodium azide (CAS 26628-22-8)

• CAS Number:

  9007-83-4

• Conjugate:

  Purified, with BSA