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JJKK 048

CAT: 0804-HY-108613-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-108613-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
JJKK 048 is a highly selective and potent monoacylglycerol lipase (MAGL) inhibitor with IC50 values of 214 pM, 275 pM and 363 pM for human, rat, and mouse MAGL. JJKK 048 displays low cross-reactivity with other endocannabinoid targets. JJKK 048 can be used in the research of diseases such as cancer, neurodegenerative diseases, and pain[1][2].
CAS Number
1515855-97-6
UNSPSC
12352005
Hazard Statement
H315, H319
Target
MAGL
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease
Applications
Neuroscience-Neuromodulation
Field of Research
Cancer; Neurological Disease
Assay Protocol
https://www.medchemexpress.com/JJKK_048.html
Purity
99.55
Solubility
DMSO : 33.33 mg/mL (ultrasonic; warming; heat to 60°C)
Smiles
O=C(N1CCC(C(C2=CC=C(OCO3)C3=C2)C4=CC=C(OCO5)C5=C4)CC1)N6N=CN=C6
Molecular Formula
C23H22N4O5
Molecular Weight
434.44
Precautions
H315, H319
References & Citations
[1]Aaltonen N, et al. In Vivo Characterization of the Ultrapotent Monoacylglycerol Lipase Inhibitor {4-[bis- (benzo[d][1,3]dioxol-5-yl) methyl]-piperidin-1-yl} (1H-1,2,4-triazol-1-yl) methanone (JJKK-048) . J Pharmacol Exp Ther. 2016 Oct;359 (1) :62-72.|[2]Aaltonen N, et al. Piperazine and piperidine triazole ureas as ultrapotent and highly selective inhibitors of monoacylglycerol lipase. Chem Biol. 2013 Mar 21;20 (3) :379-90.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C, 3 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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Alternative Products

CatalogName
452854-01JJKK 048
A19924-50JJKK 048 50mg
A19924-5JJKK 048 5mg
A19924-25JJKK 048 25mg
A19924-100JJKK 048 100mg
A19924-10JJKK 048 10mg
A19924-500JJKK 048 500mg
A19924-2JJKK 048 2mg
A19924-10mM-DJJKK 048 10mM * 1mL in DMSO

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