Promazine

• Description:

  Promazine (Romtiazin) is an antipsychotic and a dopamine receptor D2 antagonist. Promazine inhibits dopaminergic neurotransmission[1][2].

• Product Name Alternative:

  Romtiazin; Ampazine; Berophen

• UNSPSC:

  12352005

• Hazard Statement:

  H302

• Target:

  Dopamine Receptor

• Type:

  Reference compound

• Related Pathways:

  GPCR/G Protein; Neuronal Signaling

• Field of Research:

  Neurological Disease

• Assay Protocol:

  https://www.medchemexpress.com/promazine.html

• Solubility:

  10 mM in DMSO

• Smiles:

  CN(C)CCCN1C2=C(C=CC=C2)SC3=CC=CC=C13

• Molecular Formula:

  C17H20N2S

• Molecular Weight:

  284.42

• Precautions:

  P264-P270-P330-P501

• References & Citations:

  [1]Myers PR, et al. Characterization of a depolarizing dopamine response in a vertebrate neuronal somatic cell hybrid. J Cell Physiol. 1977;91 (1) :103-118. |[2]Gareri P, et al. Conventional and atypical antipsychotics in the elderly : a review. Clin Drug Investig. 2003;23 (5) :287-322. |[3]Tatsumi M, et al. Pharmacological profile of neuroleptics at human monoamine transporters. Eur J Pharmacol. 1999;368 (2-3) :277-283.

• Shipping Conditions:

  Room temperature

• Scientific Category:

  Reference compound1

• Clinical Information:

  Launched

• Isoform:

  D2 Receptor

• CAS Number:

  58-40-2