E6 Berbamine

• Description :

  E6 Berbamine (Berbamine p-nitrobenzoate) is a potent calmodulin (CaM) antagonist. E6 Berbamine inhibits the activity of calmodulin (CaM) -dependent myosin light chain kinase (MLCK), with a Ki of 0.95 μM[1]. E6 Berbamine also shows anti-leukemia activities, with an IC50 of 2.13 μM in K562 cells[2].

• Product Name Alternative :

  Berbamine p-nitrobenzoate

• UNSPSC :

  12352005

• Target :

  Calmodulin

• Type :

  Reference compound

• Related Pathways :

  Membrane Transporter/Ion Channel

• Field of Research :

  Cancer

• Assay Protocol :

  https://www.medchemexpress.com/e6-berbamine.html

• Smiles :

  COC1=C(OC2=CC3=C(C=C2OC)CCN4C)C5=C(C=C1OC)CCN(C)[C@@]5(CC6=CC=C(C(OC7=CC=C(C=C7)C[C@@]34[H])=C6)OC(C8=CC=C(C=C8)[N+]([O-])=O)=O)[H]

• Molecular Formula :

  C44H43N3O9

• Molecular Weight :

  757.83

• References & Citations :

  [1]Z Y Hu, et al. Interaction of berbamine compound E6 and calmodulin-dependent myosin light chain kinase. Biochem Pharmacol. 1992 Oct 20;44 (8) :1543-7. |[2]Jinwen Xie, et al. Berbamine derivatives: a novel class of compounds for anti-leukemia activity. Eur J Med Chem. 2009 Aug;44 (8) :3293-8.

• Shipping Conditions :

  Room temperature

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported

• CAS Number :

  [114784-59-7]