Berbamine

CAT: 0804-HY-N0714Size: 1 EachDry Ice: NoHazardous: No

1 / 1

CAT#:0804-HY-N0714Size:1 Each

Selected

24/48H Stock Items & 2 to 6 Weeks non Stock Items.

Quick Request Actions

CAS Number

478-61-5

Type

Natural Products

Related Pathways

Autophagy;NF-κB

Applications

Cancer-programmed cell death

Field of Research

Cancer; Cardiovascular Disease

Assay Protocol

https://www.medchemexpress.com/Berbamine.html

Purity

99.58

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

COC1=C(OC2=CC([C@]3([H])CC(C=C4)=CC=C4O5)=C(CCN3C)C=C2OC)C([C@@]6([H])CC7=CC=C(O)C5=C7)=C(CCN6C)C=C1OC

Molecular Weight

608.72

References & Citations

[1]Liang Y, et al. Berbamine, a novel nuclear factor kappaB inhibitor, inhibits growth and induces apoptosis in human myeloma cells. Acta Pharmacol Sin. 2009 Dec;30(12):1659-65.|[2]Meng Z, et al. Berbamine inhibits the growth of liver cancer cells and cancer-initiating cells by targeting Ca²⁺/calmodulin-dependent protein kinase II. Mol Cancer Ther. 2013 Oct;12(10):2067-77.Biomed Pharmacother. 2024 Aug 15:179:117309.|Chemrxiv. Oct 12, 2021.|Drug Des Devel Ther. 2022 Jan 11;16:129-141.|Mol Pharm. 2022 Oct 21.|Pharmaceuticals. 2024 Nov 25.|PLoS Pathog. 2023 Jan 26;19(1):e1011131.|Cell Stress Chaperones. 2021 Jan 6.|J Ethnopharmacol. 2022 Dec 7;303:116025.|J Periodontol. 2024 Jul 5.|Patent. US20220017867A1.

Shipping Conditions

Room Temperature

Storage Conditions

-20°C, 3 years; 4°C, 2 years (Powder)

Clinical Information

Launched

Chemical Information

(+)-Berbamine

Berbamine is a bisbenzylisoquinoline alkaloid and a member of isoquinolines.

CAS Number	478-61-5
PubChem CID	275182
IUPAC Name	(1S,14R)-20,21,25-trimethoxy-15,30-dimethyl-7,23-dioxa-15,30-diazaheptacyclo[22.6.2.23,6.18,12.114,18.027,31.022,33]hexatriaconta-3(36),4,6(35),8,10,12(34),18,20,22(33),24,26,31-dodecaen-9-ol
Molecular Formula	C37H40N2O6
Molecular Weight	608.7
XLogP	6.1
Topological Polar Surface Area	72.9
Hydrogen Bond Donor Count	1
Hydrogen Bond Acceptor Count	8
Rotatable Bond Count	3
Heavy Atom Count	45
Formal Charge	0
Complexity	963

SMILES

CN1CCC2=CC(=C3C=C2[C@@H]1CC4=CC=C(C=C4)OC5=C(C=CC(=C5)C[C@@H]6C7=C(O3)C(=C(C=C7CCN6C)OC)OC)O)OC

InChI

InChI=1S/C37H40N2O6/c1-38-14-12-24-19-32(41-3)33-21-27(24)28(38)16-22-6-9-26(10-7-22)44-31-18-23(8-11-30(31)40)17-29-35-25(13-15-39(29)2)20-34(42-4)36(43-5)37(35)45-33/h6-11,18-21,28-29,40H,12-17H2,1-5H3/t28-,29+/m0/s1

InChIKey

DFOCUWZXJBAUSQ-URLMMPGGSA-N

Chemical Structure

2D Structure

CAS: 478-61-5

CID: 275182

Formula: C37H40N2O6

MW: 608.7

Interactive 3D Structure

Loading 3D structure...

View on PubChem Raw 3D data

Computed Properties

Property	Value
Molecular Weight	608.7
XLogP3	6.1
Hydrogen Bond Donor Count	1
Hydrogen Bond Acceptor Count	8
Rotatable Bond Count	3
Exact Mass	608.28863700
Monoisotopic Mass	608.28863700
Topological Polar Surface Area	72.9 Å²
Heavy Atom Count	45
Formal Charge	0
Complexity	963
Isotope Atom Count	0
Defined Atom Stereocenter Count	2
Undefined Atom Stereocenter Count	0
Defined Bond Stereocenter Count	0
Undefined Bond Stereocenter Count	0
Covalently-Bonded Unit Count	1
Compound Is Canonicalized	Yes

Related Products

Catalog	Name
HY-N0716	Berberine
HY-N0716A-01	Berberine (hemisulfate)
HY-147246-01	Berberine ursodeoxycholate
HY-N0716B-01	Berberine (sulfate)
HY-18258-01	Berberine (chloride)
HY-18258S	Berberine-d6 (chloride)
HY-17577-01	Berberine (chloride hydrate)
HY-N0716BR-01	Berberine (sulfate) (Standard)
HY-18258R-01	Berberine (chloride) (Standard)
HY-N0716AR-01	Berberine (hemisulfate) (Standard)

Alternative Products

Catalog	Name
M18601-01	Berbamine
442591-01	(+) -Berbamine Dihydrochloride
AB0929	Hydrochloride Berbamine
A14794-100	Berbamine 100mg
A14794-2	Berbamine 2mg
AR-B06914-01	Berbamine DiHCl
C09452-1g	Berbamine dihydrochloride

Berbamine

Chemical Information

Related Products

Alternative Products

Popular Products