Anti-CD5 (Mantle Cell Lymphoma Marker)(B-B8), Biotin conjugate

• Description:

  This antibody recognizes a 67 kDa transmembrane protein which is identified as CD5. The CD5 antigen is found on 95% of thymocytes and 72% of peripheral blood lymphocytes. In lymph nodes, the main reactivity is observed in T cell areas. Anti-CD5 is a pan T-cell marker that also reacts with a range of neoplastic B-cells, e.g. chronic lymphocytic leukemia/small lymphocytic lymphoma (CLL/SLL), mantle cell lymphoma, and a subset (~10%) of diffuse large B-cell lymphoma. CD5 aberrant expression is useful in making a diagnosis of mature T-cell neoplasms. Note that this MAb is not suitable for frozen tissues.

• Synonyms:

  CD5 antigen (p56 62), LEU1, Ly12, LyA, Lymphocyte antigen T1/Leu-1, Lymphocyte glycoprotein T1/Leu1, T-cell surface glycoprotein CD5

• UNSPSC:

  41116161

• UNSPSC Description:

  Primary and secondary antibodies for multiple methodology immunostaining detection application

• Gene Name:

  CD5

• Gene ID:

  921

• NCBI Gene ID:

  58685

• UniProt:

  P06127

• Cellular Locus:

  Plasma membrane

• Host:

  Mouse

• Species Reactivity:

  Human

• Immunogen:

  T cells activated with PHA

• Target Antigen:

  CD5

• Clonality:

  Monoclonal

• Isotype:

  IgG1 κ

• Clone:

  B-B8

• Conjugation:

  Biotin

• Disease:

  Tumor

• Source:

  Animal

• Applications:

  Functional studies (published) | Flow, surface (expected) | IF (expected)

• Validated Applications:

  FC, IF

• Field of Research:

  Immunology

• Positive Control:

  293T, Ramos, or MOLT-4 Cells. Tonsil.

• Concentration:

  0.1 mg/mL

• Buffer:

  PBS, 0.1% BSA, 0.05% azide

• Molecular Weight:

  67 kDa

• Additionnal Information:

  Not suitable for frozen tissues|Flow cytometry: 0.5-1 ug/million cells|Immunofluorescence: 0.5-1 ug/mL|Optimal dilution for a specific application should be determined by user

• References & Citations:

  Note: References for this clone sold by other suppliers may be listed for expected applications. Inf Immunity (1996) 64(5): 1595-1599. (cell depletion) Br J Haematol (2013) 163: 182-193. (antibody internalization)

• Shipping Conditions:

  Room temperature

• Storage Conditions:

  4°C; Stable at room temperature or 37°C (98°F) for 7 days.

• Shelf Life:

  2 years

• CAS Number:

  9007-83-4