Sarecycline (hydrochloride)

Sarecycline (hydrochloride)

• CAS Number: 1035979-44-2
• UNSPSC Description: Sarecycline hydrochloride is an orally active narrow-spectrum tetracycline derivative antibiotic. Sarecycline hydrochloride has anti-inflammatory activity. Sarecycline hydrochloride inhibits the activity of Gram-positive bacteria and several types of keratobacterium acnes. Sarecycline hydrochloride interferes with tRNA accommodation and tethers mRNA to the 70S ribosome. Sarecycline hydrochloride can be used to study moderate to severe acne [1][2][3][4][5][6].
• Target Antigen: Antibiotic; Bacterial; DNA/RNA Synthesis
• Type: Reference compound
• Related Pathways: Anti-infection;Cell Cycle/DNA Damage
• Field of Research: Infection
• Assay Protocol: https://www.medchemexpress.com/sarecycline-hydrochloride.html
• Smiles: [H]Cl.O[C@]12[C@](C[C@@]3([H])C(C(C4=C(O)C=CC(CN(C)OC)=C4C3)=O)=C2O)([H])[C@@H](C(O)=C(C1=O)C(N)=O)N(C)C
• Molecular Weight: 523.96
• References & Citations: [1]Zhanel G, Critchley I, Lin LY, Alvandi N. Microbiological Profile of Sarecycline, a Novel Targeted Spectrum Tetracycline for the Treatment of Acne Vulgaris. Antimicrob Agents Chemother. 2018;63(1):e01297-18. Published 2018 Dec 21.|[2]Moore AY, Charles JEM, Moore S. Sarecycline: a narrow spectrum tetracycline for the treatment of moderate-to-severe acne vulgaris. Future Microbiol. 2019;14(14):1235-1242.|[3]Batool Z, et al. Sarecycline interferes with tRNA accommodation and tethers mRNA to the 70S ribosome. Proc Natl Acad Sci U S A. 2020;117(34):20530-20537.|[4]Butler MS, et al. Antibiotics in the clinical pipeline in 2013. J Antibiot (Tokyo). 2013 Oct;66(10):571-91.|[5]Moore AY, et al. Sarecycline: a narrow spectrum tetracycline for the treatment of moderate-to-severe acne vulgaris. Future Microbiol. 2019 Sep;14(14):1235-1242. |[6]Bunick CG, et al. Antibacterial Mechanisms and Efficacy of Sarecycline in Animal Models of Infection and Inflammation. Antibiotics (Basel). 2021 Apr 15;10(4):439. Microbiol Spectr. 2022 Dec 8;e0323822.|Microbiol Spectr. 2023 May 4;e0071823.|Pharmaceutics. 2021, 13(12), 2085.|Clin Exp Pharmacol Physiol. 2023 Apr 22.
• Shipping Conditions: Room Temperature