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Sarecycline

CAT: 0804-HY-16770Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-16770Size:1 Each
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Description
Sarecycline is an orally effective narrow-spectrum tetracycline derivative antibiotic. Sarecycline has anti-inflammatory activity. Sarecycline inhibits the activity of Gram-positive bacteria and several types of keratobacterium acnes. Sarecycline interferes with tRNA accommodation and tethers mRNA to the 70S ribosome. Sarecycline can be used to study moderate to severe acne[1][2][3][4][5][6].
CAS Number
1035654-66-0
Product Name Alternative
P-005672
UNSPSC
12352005
Hazard Statement
H302-H312-H332
Target
Antibiotic; Bacterial; DNA/RNA Synthesis
Type
Reference compound
Related Pathways
Anti-infection; Cell Cycle/DNA Damage
Applications
COVID-19-anti-virus
Field of Research
Infection
Assay Protocol
https://www.medchemexpress.com/sarecycline.html
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
O[C@@](C(O)=C(C(C1=C(C=C2)O)=O)[C@](CC1=C2CN(C)OC)([H])C3)(C(C(C(N)=O)=C4O)=O)[C@]3([H])[C@@H]4N(C)C
Molecular Formula
C24H29N3O8
Molecular Weight
487.50
Precautions
P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P363-P501
References & Citations
[1]Zhanel G, et al. Microbiological Profile of Sarecycline, a Novel Targeted Spectrum Tetracycline for the Treatment of Acne Vulgaris. Antimicrob Agents Chemother. 2018 Dec 21;63 (1) :e01297-18.|[2]Moore AY, et al. Sarecycline: a narrow spectrum tetracycline for the treatment of moderate-to-severe acne vulgaris. Future Microbiol. 2019 Sep;14 (14) :1235-1242.|[3]Batool Z, et al. Sarecycline interferes with tRNA accommodation and tethers mRNA to the 70S ribosome. Proc Natl Acad Sci U S A. 2020 Aug 25;117 (34) :20530-20537. |[4]Butler MS, et al. Antibiotics in the clinical pipeline in 2013. J Antibiot (Tokyo) . 2013 Oct;66 (10) :571-91.|[5]Moore AY, et al. Sarecycline: a narrow spectrum tetracycline for the treatment of moderate-to-severe acne vulgaris. Future Microbiol. 2019 Sep;14 (14) :1235-1242. |[6]Bunick CG, et al. Antibacterial Mechanisms and Efficacy of Sarecycline in Animal Models of Infection and Inflammation. Antibiotics (Basel) . 2021 Apr 15;10 (4) :439.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
Launched
Isoform
Tetracycline
Citation 01
Clin Exp Pharmacol Physiol. 2023 Jul;50 (7) :604-609.|Microbiol Spectr. 2023 Feb 14;11 (1) :e0323822.|Microbiol Spectr. 2023 Jun 15;11 (3) :e0071823.|Pharmaceutics. 2021 Dec 5;13 (12) :2085.

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