Tasimelteon

Tasimelteon

• CAS Number: 609799-22-6
• UNSPSC Description: Tasimelteon (BMS-214778) is an orally active and selective dual melatonin receptor agonist (DMRA). Tasimelteon has 2.1-4.4 times greater affinity for the MT2 receptor than for the MT1 receptor. Tasimelteon is a circadian regulator and has the potential for Non-24-Hour Sleep-Wake Disorder (Non-24)[1][2].
• Target Antigen: Melatonin Receptor
• Type: Reference compound
• Related Pathways: GPCR/G Protein;Neuronal Signaling
• Applications: Neuroscience-Neuromodulation
• Field of Research: Neurological Disease; Endocrinology
• Assay Protocol: https://www.medchemexpress.com/Tasimelteon.html
• Solubility: DMSO : ≥ 33 mg/mL
• Smiles: [H][C@]1(C2=C3C(OCC3)=CC=C2)[C@@](CNC(CC)=O)([H])C1
• Molecular Weight: 245.322
• References & Citations: [1]Christian Lavedan, et al. Tasimelteon: a selective and unique receptor binding profile. Neuropharmacology. 2015 Apr;91:142-7.|[2]Keating GM, et al. Tasimelteon: A Review in Non-24-Hour Sleep-Wake Disorder in Totally Blind Individuals. CNS Drugs. 2016 Mar 22.
• Shipping Conditions: Room Temperature
• Clinical Information: Launched