Tasimelteon-d5

Tasimelteon-d5

• CAS Number: 1962124-51-1
• UNSPSC Description: Tasimelteon-d5 is the deuterium labeled Tasimelteon. Tasimelteon (BMS-214778) is an orally active and selective dual melatonin receptor agonist (DMRA). Tasimelteon has 2.1-4.4 times greater affinity for the MT2 receptor than for the MT1 receptor. Tasimelteon is a circadian regulator and has the potential for Non-24-Hour Sleep-Wake Disorder (Non-24)[1][2].
• Target Antigen: Isotope-Labeled Compounds; Melatonin Receptor
• Type: Isotope-Labeled Compounds
• Related Pathways: GPCR/G Protein;Neuronal Signaling;Others
• Field of Research: Neurological Disease; Endocrinology
• Solubility: 10 mM in DMSO
• Smiles: [H][C@]1(C[C@H]1CNC(C([2H])(C([2H])([2H])[2H])[2H])=O)C2=C3CCOC3=CC=C2
• Molecular Weight: 250.35
• References & Citations: [1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216. |[2]Christian Lavedan, et al. Tasimelteon: a selective and unique receptor binding profile. Neuropharmacology. 2015 Apr;91:142-7.|[3]Keating GM, et al. Tasimelteon: A Review in Non-24-Hour Sleep-Wake Disorder in Totally Blind Individuals. CNS Drugs. 2016 Mar 22.
• Shipping Conditions: Room temperature
• Clinical Information: No Development Reported