Tacalcitol

Tacalcitol (1,24 (R) -Dihydroxyvitamin D3; 1.alpha.,24R-Dihydroxyvitamin D3) can promote normal bone growth by regulating calcium ions. Tacalcitol inhibits cancer cell proliferation and migration. Tacalcitol can be used in the research of inflammation, cancer, and skin diseases[1][2][3][4][5].

57333-96-7

1,24 (R) -Dihydroxyvitamin D3; 1.alpha.,24R-Dihydroxyvitamin D3

12352211

H300

Interleukin Related; VD/VDR

Reference compound

Immunology/Inflammation; Vitamin D Related/Nuclear Receptor

Metabolism-sugar/lipid metabolism

Cancer; Metabolic Disease; Inflammation/Immunology

https://www.medchemexpress.com/Tacalcitol.html

99.71

DMSO : ≥ 100 mg/mL

C=C1[C@H](C[C@@H](C/C1=C/C=C2[C@]3([C@@](C)([C@H](CC3)[C@@H](CC[C@H](C(C)C)O)C)CCC/2)[H])O)O

C27H44O3

416.64

H300

[1]Rostkowska-Nadolska B, et al. Vitamin D derivatives: calcitriol and tacalcitol inhibits interleukin-6 and interleukin-8 expression in human nasal polyp fibroblast cultures. Adv Med Sci. 2010;55 (1) :86-92.|[2]Kobayashi T, et al. 1 alpha,24R-dihydroxyvitamin D3 has an ability comparable to that of 1 alpha,25-dihydroxyvitamin D3 to induce keratinocyte differentiation. J Dermatol. 1990 Nov;17 (11) :707-9.|[3]Matsumoto K, et al. K. Effect of 1,24R-dihydroxyvitamin D3 on the growth of human keratinocytes. J Dermatol. 1990 Feb;17 (2) :97-103.|[4]Emanuelsson I, et al. Vitamin D Analogues Tacalcitol and Calcipotriol Inhibit Proliferation and Migration of T98G Human Glioblastoma Cells. Basic Clin Pharmacol Toxicol. 2018 Aug;123 (2) :130-136.|[5]Sato H, et al. Pharmacological profiles of high-concentration (20 microg/g) tacalcitol ointment: effects on cutaneous inflammation, epidermal proliferation, and differentiation in mice. J Dermatol. 2003 Jul;30 (7) :510-24.

Room Temperature

4°C (Powder, protect from light, stored under nitrogen)

Reference compound1