CD35 / CR1 (E11), 0.2mg/mL

• Description :

  Recognizes a protein of 210-220 kDa, which is identified as the complement receptor 1 (CR1) /CD35. This MAb is specific for a site in CR1 that is distal from the C3b-binding site, so that it is unable to block CR1 activity. This MAb is highly specific to CR1 and shows no cross-reaction with CR2. The primary function of CR1 is to serve as the cellular receptor for C3b and C4b, the most important components of the complement system leading to clearance of foreign macromolecules. The Knops blood group system is a system of antigens located on this protein. Follicular dendritic cells (FDC) are restricted to the B-cell regions of secondary lymphoid follicles. They are CD21 /CD35 /CD1a-. This MAb labels follicular dendritic cells and follicular dendritic cell sarcoma.Primary antibodies are available purified, or with a selection of fluorescent CF® Dyes and other labels. CF® Dyes offer exceptional brightness and photostability. Note: Conjugates of blue fluorescent dyes like CF®405S and CF®405M are not recommended for detecting low abundance targets, because blue dyes have lower fluorescence and can give higher non-specific background than other dye colors.

• Synonyms :

  C3 binding protein, C3b/C4b receptor, C3BR, C4BR, Complement Component (3b/4b) receptor 1 including Knops blood group system, Complement receptor type 1, KN, Knops blood group antigen

• UNSPSC :

  41116161

• UNSPSC Description :

  Primary and secondary antibodies for multiple methodology immunostaining detection application

• Gene Name :

  CR1

• Gene ID :

  1378

• NCBI Gene ID :

  334019

• UniProt :

  P17927

• Swiss Prot :

  P17927

• Host :

  Mouse

• Species Reactivity :

  Baboon, Cynomolgus, Human, Rhesus macaque

• Reactivity :

  CD35|CR1

• Immunogen :

  Intact human monocytes

• Target Antigen :

  CD35 | CR1

• Clonality :

  Monoclonal

• Clone :

  E11

• Type :

  Primary

• Source :

  Animal

• Origin :

  Animal

• Applications :

  Flow, surface (published) |ELISA (published) |IHC, FFPE (verified) |WB (published)

• Field of Research :

  Immunology

• Positive Control :

  Follicular dendritic cells (FDC) in tonsil

• Stability :

  2 years

• Concentration :

  0.2 mg/mL

• Buffer :

  PBS, 0.05% BSA, 0.05% azide

• Molecular Weight :

  210-220 kDa

• References & Citations :

  Note: References for this clone sold by other suppliers may be listed for expected applications. J Immunol (1999) 162:7549-7554. (WB) Clin Exp Immunol (2005) 143: 274-280. (ELISA) Int Immunol (2013) 25(1): 25-33. (Flow, surface)

• Shipping Conditions :

  RT (ND)

• Storage Conditions :

  Stable at room temperature or 37°C (98°F) for 7 days.

• Shelf Life :

  Guaranteed for at least 24 months from date of receipt when stored as recommended

• Fragment :

  IgG1, kappa

• Species :

  Mus musculus (mouse), BSA from bovine serum (Bos taurus) or recombinant BSA produced in Chinese hamster ovary cells.

• Classification :

  PBS, 0.05% BSA, 0.05% sodium azide (CAS 26628-22-8)

• CAS Number :

  9007-83-4

• Conjugate :

  Purified, with BSA