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CGP36216 (hydrochloride)

CAT: 0804-HY-103518A-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-103518A-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
CGP36216 hydrochloride is a selective antagonist at GABA presynaptic receptor. CGP36216 binds to GABAB receptor with a Ki value of 0.3 μM. CGP36216 hydrochloride can be used for research of anxiety and trauma-related disorders[1][2].
CAS Number
1781834-71-6
UNSPSC
12352211
Target
GABA Receptor
Type
Reference compound
Related Pathways
Membrane Transporter/Ion Channel; Neuronal Signaling
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/cgp36216-hydrochloride.html
Solubility
10 mM in DMSO
Smiles
O=P(CC)(CCCN)O.Cl
Molecular Formula
C5H15ClNO2P
Molecular Weight
187.60
References & Citations
[1]William Howson, et al. Biological activity of 3-aminopropyl (methyl) phosphinic acid, a potent and selective GABAB agonist with CNS activity. Bioorganic & Medicinal Chemistry Letters. Volume 3, Issue 4, April 1993, Pages 515-518.|[2]J Ong, et al. CGP 36216 is a selective antagonist at GABA (B) presynaptic receptors in rat brain. Eur J Pharmacol. 2001 Mar;415 (2-3) :191-5.|[3]Ming Chen, et al. Morphine disinhibits glutamatergic input to VTA dopamine neurons and promotes dopamine neuron excitation. Elife. 2015 Jul 24:4:e09275.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

Chemical Information

CGP 36216 hydrochloride
CAS Number1781834-71-6
PubChem CID90488815
IUPAC Name3-aminopropyl(ethyl)phosphinic acid;hydrochloride
Molecular FormulaC5H15ClNO2P
Molecular Weight187.60
Topological Polar Surface Area63.3
Hydrogen Bond Donor Count3
Hydrogen Bond Acceptor Count3
Rotatable Bond Count4
Heavy Atom Count10
Formal Charge0
Complexity116
SMILES
CCP(=O)(CCCN)O.Cl
InChI
InChI=1S/C5H14NO2P.ClH/c1-2-9(7,8)5-3-4-6;/h2-6H2,1H3,(H,7,8);1H
InChIKey
CFQFXUJBWMPODB-UHFFFAOYSA-N
Chemical Structure
2D Structure
2D structure of CGP 36216 hydrochloride
CAS: 1781834-71-6
CID: 90488815
Formula: C5H15ClNO2P
MW: 187.60
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight187.60
Hydrogen Bond Donor Count3
Hydrogen Bond Acceptor Count3
Rotatable Bond Count4
Exact Mass187.0528934
Monoisotopic Mass187.0528934
Topological Polar Surface Area63.3 Ų
Heavy Atom Count10
Formal Charge0
Complexity116
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count2
Compound Is CanonicalizedYes

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