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IA-14069

CAT: 0804-HY-163102-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-163102-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
IA-14069 is an orally active tumor necrosis factor-α (TNF-α) inhibitor. IA-14069 binds directly to TNF-α and TNF-α-triggered signaling (p-IκBα and NF-κB p65) activities. Additionally, IA-14069 exerts a suppressive effect on Dextran sodium sulfate (DSS) -induced colitis. IA-14069 can be used for the research of Rheumatoid arthritis (RA) and inflammatory bowel disease (IBD)[2].
CAS Number
2271216-04-5
UNSPSC
12352005
Target
TNF Receptor
Type
Reference compound
Related Pathways
Apoptosis
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/ia-14069.html
Purity
99.93
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
O=C(C1=C(C2=C(F)C=CC(F)=C2)OC3=CC(Cl)=CC=C3C1=O)OC(C)(C)C
Molecular Formula
C20H15ClF2O4
Molecular Weight
392.78
References & Citations
[1]Park S, et al. THU0047 IA-14069, A NOVEL SMALL-MOLECULE INHIBITOR DIRECT-TARGETING TUMOR NECROSIS FACTOR-α, ATTENUATES COLLAGEN INDUCED ARTHRITIS. Annals of the Rheumatic Diseases. 2019, 78:291|[2]Okki Cho, et al. TNF targeting small molecule attenuates colonic inflammation in acute DSS-induced colitis mice. The Journal of Immunology, Volume 202, Issue 1_Supplement, May 2019, Page 52.11
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
Phase 1

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