Products for Research Use Only
RegisterLogin

Escin IA

CAT: 0804-HY-N0554-01Size: 5 mgDry Ice: NoHazardous: No
Product image 1
1 / 1
CAT#:0804-HY-N0554-01Size:5 mg
Selected
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Quick Request Actions
Description
Escin IA is a triterpene saponin isolated from Aesculus hippocastanum, which inhibits HIV-1 protease with IC50 values of 35 μM. Escin IA has anti-TNBC metastasis activity, and its action mechanisms involved inhibition of epithelial-mesenchymal transition process by down-regulating LOXL2 expression[1][2].
CAS Number
123748-68-5
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
HIV Protease
Type
Natural Products
Related Pathways
Anti-infection; Metabolic Enzyme/Protease
Applications
Neuroscience-Neuromodulation
Field of Research
Cancer; Infection
Assay Protocol
https://www.medchemexpress.com/escin-ia.html
Purity
99.59
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
OC[C@]1([C@H]2OC(C)=O)[C@](CC(C)(C)[C@H]2OC(/C(C)=C/C)=O)([H])C3=CC[C@@]4([H])[C@@](C)(CC[C@]5([H])[C@@]4(CC[C@H](O[C@@](O[C@H](C(O)=O)[C@@H](O[C@]([C@@H]([C@@H](O)[C@@H]6O)O)([H])O[C@@H]6CO)[C@@H]7O)([H])[C@@H]7O[C@]([C@@H]([C@@H](O)[C@@H]8O)O)([H])O[C@@H]8CO)[C@]5(C)CO)C)[C@]3(C)C[C@H]1O
Molecular Formula
C55H86O24
Molecular Weight
1131.26
Precautions
H302, H315, H319, H335
References & Citations
[1]Yang XW, et al. Anti-HIV-1 protease triterpenoid saponins from the seeds of Aesculus chinensis. J Nat Prod. 1999 Nov;62 (11) :1510-3.|[2]Wang Y, et al. Escin Ia suppresses the metastasis of triple-negative breast cancer by inhibiting epithelial-mesenchymal transition via down-regulating LOXL2 expression. Oncotarget. 2016 Apr 26;7 (17) :23684-99.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, protect from light)
Scientific Category
Natural Products
Clinical Information
No Development Reported

Related Products

CatalogName
HY-B2114-01Escin
HY-107248-01Escin IIa
HY-N7706Escin Ie
HY-107247-01Escin IIb
HY-N0555-01Escin IB
HY-N0555REscin IB (Standard)
HY-124790KSP-IA
HY-N13692Cinchonain Ia
HY-N13082Deacetylescin Ia
HY-N15226Butyrolactone Ia

Alternative Products

CatalogName
MBS575884Escin
FE145233-01Escin IA
IGA80083-01Escin Iib
MBS3612993-01beta-Escin

Popular Products