11R-VIVIT (TFA)

11R-VIVIT (TFA)

• UNSPSC Description: 11R-VIVIT TFA is a cell-permeable nuclear factor of activated T cells (NFAT) inhibitor. 11R-VIVIT TFA can be used for the research of podocyte and diabetic nephropathy[1].
• Target Antigen: Nuclear Factor of activated T Cells (NFAT)
• Type: Peptides
• Related Pathways: Immunology/Inflammation
• Field of Research: Metabolic Disease
• Assay Protocol: https://www.medchemexpress.com/11r-vivit-tfa.html
• Purity: 99.22
• Solubility: H2O : 100 mg/mL (ultrasonic)
• Smiles: O=C([C@H]1N(CCC1)C(CNC([C@H](C)NC([C@H](CCSC)NC(CNC(CNC(CNC([C@H](CCCNC(N)=N)NC([C@H](CCCNC(N)=N)NC([C@H](CCCNC(N)=N)NC([C@H](CCCNC(N)=N)NC([C@H](CCCNC(N)=N)NC([C@H](CCCNC(N)=N)NC([C@H](CCCNC(N)=N)NC([C@H](CCCNC(N)=N)NC([C@H](CCCNC(N)=N)NC([C@H](CCCNC(N)=N)NC([C@@H](N)CCCNC(N)=N)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)N[C@@H](CC2=CN=CN2)C(N3[C@@H](CCC3)C(N[C@@H](C(C)C)C(N[C@@H]([C@@H](C)CC)C(N[C@@H](C(C)C)C(N[C@@H]([C@@H](C)CC)C(N[C@@H]([C@H](O)C)C(NCC(N4[C@@H](CCC4)C(N[C@H](C(N[C@@H](CCC(O)=O)C(N[C@H](C(O)=O)CCC(O)=O)=O)=O)CC5=CN=CN5)=O)=O)=O)=O)=O)=O)=O)=O)=O.O=C(O)C(F)(F)F
• Molecular Weight: 3573.15
• References & Citations: [1]Zhang L, et al. NFAT2 inhibitor ameliorates diabetic nephropathy and podocyte injury in db/db mice. Br J Pharmacol. 2013;170(2):426-439.Acta Pharmacol Sin. 2021 Dec 22.|Am J Respir Cell Mol Biol. 2022 Oct 13.|bioRxiv. May 18, 2022.|Elife. 2022 Aug 22;11:e79957.|Inflammopharmacology. 2023 Jul 14.|Research Square Preprint. 2021 Oct.
• Shipping Conditions: Blue Ice
• Storage Conditions: -80°C, 2 years; -20°C, 1 year (Powder, sealed storage, away from moisture)
• Clinical Information: No Development Reported