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CD11c (HC1/1), 1mg/mL

CAT: 0037-BNUM0152-50Size: 1x 50 µLDry Ice: NoHazardous: No
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CAT#:0037-BNUM0152-50Size:1x 50 µL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
CD11c, also known as Integrin, alpha X (complement component 3 receptor 4 subunit) (ITGAX), is a type I transmembrane protein found at high levels on most human dendritic cells, but also on monocytes, macrophages, neutrophils, and some B cells. It induces cellular activation and helps trigger neutrophil respiratory burst. It is expressed in hairy cell leukemias, acute non-lymphocytic leukemias, and some B-cell chronic lymphocytic leukemias. Primary antibodies are available purified, or with a selection of fluorescent CF® Dyes and other labels. CF® Dyes offer exceptional brightness and photostability. Note: Conjugates of blue fluorescent dyes like CF®405S and CF®405M are not recommended for detecting low abundance targets, because blue dyes have lower fluorescence and can give higher non-specific background than other dye colors.
CAS Number
9007-83-4
Synonyms
CD11 antigen-like family member B|CD11b/CD18|CD49d|Cell surface glycoprotein MAC-1 subunit alpha|Complement Component Receptor 3 Alpha|CR3 Alpha Chain (CR3A) |Integrin alpha-M|Integrin beta 2 alpha subunit|ITGAM|Leukocyte adhesion receptor MO1; Ly-40|Mac-1a|MAC1|Mac1, alpha subunit|MAC1A|Macrophage antigen alpha polypeptide; MO1A|Neutrophil adherence receptor alpha M subunit
UNSPSC
41116161
UNSPSC Description
Primary and secondary antibodies for multiple methodology immunostaining detection application
Gene Name
ITGAX
Gene ID
3687
NCBI Gene ID
248472
UniProt
P20702
Swiss Prot
P20702
Host
Mouse
Species Reactivity
Human
Reactivity
CD11c
Immunogen
Human monocytic U937 phorbol ester-treated cells
Target Antigen
CD11c
Clonality
Monoclonal
Clone
HC1/1
Type
Primary
Source
Animal
Origin
Animal
Applications
Flow (verified) |Flow, surface (published) |Functional studies (published) |IP (published)
Field of Research
Cell adhesion, Immunology
Positive Control
Human dendritic cells. Human lymph nodes and tonsils.
Stability
2 years
Concentration
1 mg/mL
Buffer
PBS, no BSA, no azide
Molecular Weight
145 kDa
References & Citations
Note: References for this clone sold by other suppliers may be listed for expected applications. Hybridoma (1988) 7:2, 167-176. (IHC) J Exp Med (1991) 174 (6): 1313-1322. (Flow; receptor activation; IP)
Shipping Conditions
RT (ND)
Storage Conditions
Stable at room temperature or 37°C (98°F) for 7 days.
Shelf Life
Guaranteed for at least 24 months from date of receipt when stored as recommended
Fragment
IgG1, kappa
Species
Mus musculus (mouse)
Classification
PBS, no BSA, no sodium azide (CAS 26628-22-8)
Conjugate
Purified, BSA-free

UniProtKB · P20702

Integrin alpha-X

ITAX_HUMAN · Homo sapiens

View on UniProt ↗
Primary accession
P20702
Review status
UniProtKB reviewed (Swiss-Prot)
Gene
ITGAX
Protein existence
1: Evidence at protein level
Organism
Homo sapiens (Human)
Taxonomy ID
9606
Alternative names
—
EC number
—
Processing
Precursor
Secondary accessions
Q8IVA6
Protein keywords

Technical term

3D-structureDirect protein sequencingProteomics identificationReference proteome

Ligand

CalciumMagnesiumMetal-binding

Biological process

Cell adhesion

Cellular component

Cell membraneMembrane

PTM

Disulfide bondGlycoprotein

Molecular function

IntegrinReceptor

Domain

RepeatSignalTransmembraneTransmembrane helix
Product Datasheet
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