Anti-CD11c(HC1/1)

Anti-CD11c(HC1/1)

• Description: CD11c, also known as Integrin, alpha X (complement component 3 receptor 4 subunit) (ITGAX), is a type I transmembrane protein found at high levels on most human dendritic cells, but also on monocytes, macrophages, neutrophils, and some B cells. It induces cellular activation and helps trigger neutrophil respiratory burst. It is expressed in hairy cell leukemias, acute non-lymphocytic leukemias, and some B-cell chronic lymphocytic leukemias._x000D_ _x000D_ Primary antibodies are available purified, or with a selection of fluorescent CF® Dyes and other labels. CF® Dyes offer exceptional brightness and photostability. Note: Conjugates of blue fluorescent dyes like CF®405S and CF®405M are not recommended for detecting low abundance targets, because blue dyes have lower fluorescence and can give higher non-specific background than other dye colors._x000D_ _x000D_
• Synonyms: CD11 antigen-like family member B|CD11b/CD18|CD49d|Cell surface glycoprotein MAC-1 subunit alpha|Complement Component Receptor 3 Alpha|CR3 Alpha Chain (CR3A)|Integrin alpha-M|Integrin beta 2 alpha subunit|ITGAM|Leukocyte adhesion receptor MO1; Ly-40|Mac-1a|MAC1|Mac1, alpha subunit|MAC1A|Macrophage antigen alpha polypeptide; MO1A|Neutrophil adherence receptor alpha M subunit
• CAS Number: 9007-83-4
• UNSPSC: 41116161
• UNSPSC Description: Primary and secondary antibodies for multiple methodology immunostaining detection application
• Gene Name: ITGAX
• Gene ID: 3687
• NCBI Gene ID: 248472
• UniProt: P20702
• Cellular Locus: Plasma membrane
• Host: Mouse
• Species Reactivity: Human
• Immunogen: Human monocytic U937 phorbol ester-treated cells
• Target Antigen: CD11c
• Clonality: Monoclonal
• Isotype: IgG1 κ
• Clone: HC1/1
• Conjugation: Purified, with BSA
• Disease: Tumor
• Source: Animal
• Applications: Flow (verified) | Flow, surface (published) | Functional studies (published) | IP (published)
• Validated Applications: FC, FC, IP
• Field of Research: Cell adhesion, Immunology
• Positive Control: Human dendritic cells. Human lymph nodes and tonsils.
• Concentration: 0.2 mg/mL
• Buffer: PBS, 0.05% BSA, 0.05% azide
• Molecular Weight: 145 kDa
• Additionnal Information: Higher concentration may be required for direct detection using primary antibody conjugates than for indirect detection with secondary antibody|Immunofluorescence: 0.5-1 ug/mL|Flow Cytometry 0.5-1 ug/million cells/0.1 mL
• References & Citations: Note: References for this clone sold by other suppliers may be listed for expected applications. Hybridoma (1988) 7:2, 167-176. (IHC) J Exp Med (1991) 174 (6): 1313-1322. (Flow; receptor activation; IP)
• Shipping Conditions: Room temperature
• Storage Conditions: 4°C; Stable at room temperature or 37°C (98°F) for 7 days.
• Shelf Life: 2 years