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Levetiracetam-d3

CAT: 0804-HY-B0106S1-01Size: 10 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-B0106S1-01Size:10 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Levetiracetam-d3 is the deuterium labeled Levetiracetam. Levetiracetam, an antiepileptic agent, binds the synaptic vesicle protein SV2A. Levetiracetam enhances Temozolomide effect on glioblastoma stem cell proliferation and apoptosis. Levetiracetam modulates HDAC levels ultimately silencing MGMT, thus increasing Temozolomide effectiveness. A chemosensitizer agent[1][2].
CAS Number
1217851-16-5
Product Name Alternative
UCB L059-d3
UNSPSC
12352005
Target
DNA Methyltransferase
Type
Isotope-Labeled Compounds
Related Pathways
Epigenetics
Field of Research
Cancer; Neurological Disease
Solubility
10 mM in DMSO
Smiles
[C@@H](C(N)=O)(CC([2H])([2H])[2H])N1C(=O)CCC1
Molecular Formula
C₈H₁₁D₃N₂O₂
Molecular Weight
173.23
References & Citations
[1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53 (2) :211-216. |[2]Bianca Maria Scicchitano, et al. Levetiracetam enhances the temozolomide effect on glioblastoma stem cell proliferation and apoptosis. Cancer Cell Int. 2018 Sep 10;18:136.|[3]Delia M Talos, et al. Antiepileptic effects of levetiracetam in a rodent neonatal seizure model. Pediatr Res. 2013 Jan;73 (1) :24-30.
Shipping Conditions
Room temperature
Scientific Category
Isotope-Labeled Compounds
Clinical Information
No Development Reported

Chemical Information

Levetiracetam-d3
CAS Number1217851-16-5
PubChem CID45039653
IUPAC Name(2S)-4,4,4-trideuterio-2-(2-oxopyrrolidin-1-yl)butanamide
Molecular FormulaC8H14N2O2
Molecular Weight173.23
XLogP-0.3
Topological Polar Surface Area63.4
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count2
Rotatable Bond Count3
Heavy Atom Count12
Formal Charge0
Complexity203
SMILES
[2H]C([2H])([2H])C[C@@H](C(=O)N)N1CCCC1=O
InChI
InChI=1S/C8H14N2O2/c1-2-6(8(9)12)10-5-3-4-7(10)11/h6H,2-5H2,1H3,(H2,9,12)/t6-/m0/s1/i1D3
InChIKey
HPHUVLMMVZITSG-FYFSCIFKSA-N
Chemical Structure
2D Structure
2D structure of Levetiracetam-d3
CAS: 1217851-16-5
CID: 45039653
Formula: C8H14N2O2
MW: 173.23
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight173.23
XLogP3-0.3
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count2
Rotatable Bond Count3
Exact Mass173.124357931
Monoisotopic Mass173.124357931
Topological Polar Surface Area63.4 Ų
Heavy Atom Count12
Formal Charge0
Complexity203
Isotope Atom Count3
Defined Atom Stereocenter Count1
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

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