5β-Cholanic acid

CAT: 0804-HY-W127512-01Size: 5 mgDry Ice: NoHazardous: No
CAT#:0804-HY-W127512-01Size:5 mg
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Description
5β-Cholanic acid is a hydrophobic modifier used to modify polymer carriers. 5β-Cholanic acid can improve the acid stability, cell penetration efficiency and drug sustained release ability of nanocarriers, and optimize the oral effectiveness of delivered molecules. 5β-Cholanic acid can covalently bind to Glycol chitosan (GC) to form a GC-CA conjugate, which optimizes the hydrophobic anchoring ability of nanoparticles and enables them to be stably adsorbed on the surface of PLGA nanoparticles. Such nanoparticles can resist dissociation in the gastric acid environment and maintain positive charge to enhance endocytic uptake by intestinal epithelial cells (such as Caco-2 cells) . 5β-Cholanic acid can be used in the development of drug delivery systems[1][2].
CAS Number
[546-18-9]
UNSPSC
12352211
Hazard Statement
H302, H315, H319, H335
Target
Drug Intermediate
Type
Reference compound
Related Pathways
Others
Field of Research
Others
Assay Protocol
https://www.medchemexpress.com/5β-cholanic-acid.html
Purity
99.87
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
C[C@@]12[C@](CC[C@]2([H])[C@H](C)CCC(O)=O)([H])[C@@]3([H])[C@]([C@@]4([C@](CCCC4)([H])CC3)C)([H])CC1
Molecular Formula
C24H40O2
Molecular Weight
360.57
Precautions
H302, H315, H319, H335
References & Citations
[1]Weizhi Wang, et al. Improved oral delivery of insulin by PLGA nanoparticles coated with 5 β-cholanic acid conjugated glycol chitosan. Biomed Mater. 2021 Oct 12;16 (6) .|[2]Li T, et al. Use of glycol chitosan modified by 5beta-cholanic acid nanoparticles for the sustained release of proteins during murine embryonic limb skeletogenesis. J Control Release. 2010 May 21;144 (1) :101-8.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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