Ganoderic acid D (Standard)

• Description:

  Ganoderic acid D (Standard) is the analytical standard of Ganoderic acid D. This product is intended for research and analytical applications. Ganoderic acid D, a highly oxygenated tetracyclic triterpenoid, is the major active component of Ganoderma lucidum. Ganoderic acid D upregulates the protein expression of SIRT3 and induces the deacetylated cyclophilin D (CypD) by SIRT3. Ganoderic acid D inhibits the energy reprogramming of colon cancer cells including glucose uptake, lactate production, pyruvate and acetyl-coenzyme production in colon cancer cells[1]. Ganoderic acid D induces HeLa human cervical carcinoma apoptosis[2].

• UNSPSC:

  12352211

• Target:

  Apoptosis; Reference Standards; Sirtuin

• Type:

  Reference Standards

• Related Pathways:

  Apoptosis; Cell Cycle/DNA Damage; Epigenetics; Others

• Field of Research:

  Cancer

• Assay Protocol:

  https://www.medchemexpress.com/ganoderic-acid-d-standard.html

• Smiles:

  CC1 (C) C (CC[C@]2 (C) C3=C ([C@@]4 (C (C[C@@H] ([C@]4 (CC3=O) C) [C@H] (C) CC (CC (C) C (O) =O) =O) =O) C) [C@@H] (O) C[C@@]12[H]) =O

• Molecular Formula:

  C30H42O7

• Molecular Weight:

  514.65

• References & Citations:

  [1]Liu Z, et al. Effect of ganoderic acid D on colon cancer Warburg effect: Role of SIRT3/cyclophilin D. Eur J Pharmacol. 2018 Apr 5;824:72-77.|[2]Yue QX, et al. Proteomics characterization of the cytotoxicity mechanism of ganoderic acid D and computer-automated estimation of the possible drug target network. Mol Cell Proteomics. 2008 May;7 (5) :949-61.

• Shipping Conditions:

  Room temperature

• Scientific Category:

  Reference Standards

• CAS Number:

  108340-60-9