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PP1

CAT: 0804-HY-13804-02Size: 10 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-13804-02Size:10 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
PP1 is a potent, and Src family-selective tyrosine kinase inhibitor with IC50 of 5 and 6 nM for Lck and Fyn, respectively.
CAS Number
172889-26-8
Product Name Alternative
AGL 1872; EI 275
UNSPSC
12352005
Hazard Statement
H301
Target
Apoptosis; Src
Type
Reference compound
Related Pathways
Apoptosis; Protein Tyrosine Kinase/RTK
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/PP1.html
Purity
99.57
Solubility
DMSO : 28 mg/mL (ultrasonic)
Smiles
NC1=C2C(N(C(C)(C)C)N=C2C3=CC=C(C)C=C3)=NC=N1
Molecular Formula
C16H19N5
Molecular Weight
281.36
Precautions
H301
References & Citations
[1]Hanke JH, et al. Discovery of a novel, potent, and Src family-selective tyrosine kinase inhibitor. Study of Lck- and FynT-dependent T cell activation. J Biol Chem. 1996 Jan 12;271 (2) :695-701.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported

Chemical Information

1-Ter-Butyl-3-P-Tolyl-1h-Pyrazolo[3,4-D]Pyrimidin-4-Ylamine
CAS Number172889-26-8
PubChem CID1400
IUPAC Name1-tert-butyl-3-(4-methylphenyl)pyrazolo[3,4-d]pyrimidin-4-amine
Molecular FormulaC16H19N5
Molecular Weight281.36
XLogP2.8
Topological Polar Surface Area69.6
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count4
Rotatable Bond Count2
Heavy Atom Count21
Formal Charge0
Complexity358
SMILES
CC1=CC=C(C=C1)C2=NN(C3=NC=NC(=C23)N)C(C)(C)C
InChI
InChI=1S/C16H19N5/c1-10-5-7-11(8-6-10)13-12-14(17)18-9-19-15(12)21(20-13)16(2,3)4/h5-9H,1-4H3,(H2,17,18,19)
InChIKey
ZVPDNRVYHLRXLX-UHFFFAOYSA-N
Chemical Structure
2D Structure
2D structure of 1-Ter-Butyl-3-P-Tolyl-1h-Pyrazolo[3,4-D]Pyrimidin-4-Ylamine
CAS: 172889-26-8
CID: 1400
Formula: C16H19N5
MW: 281.36
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight281.36
XLogP32.8
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count4
Rotatable Bond Count2
Exact Mass281.16404563
Monoisotopic Mass281.16404563
Topological Polar Surface Area69.6 Ų
Heavy Atom Count21
Formal Charge0
Complexity358
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

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