Maytansinoid B

• Description:

  Maytansinoid B is a kind of ADC Cytotoxin. Maytansinoid B can be used to conjugates with antibodies to form antibody-drug conjugates (ADCs) . Maytansinoids are known as antimitotic agents, binding to tubulin and inhibiting microtubule assembly. Maytansinoids induces G2/M arrest in the cell cycle to induce apoptosis[1][2].

• UNSPSC:

  12352203

• Target:

  ADC Payload

• Type:

  ADC Related

• Related Pathways:

  Antibody-drug Conjugate/ADC Related

• Applications:

  Cancer-programmed cell death

• Field of Research:

  Cancer

• Assay Protocol:

  https://www.medchemexpress.com/maytansinoid-b.html

• Purity:

  99.06

• Solubility:

  DMSO : 100 mg/mL (ultrasonic)

• Smiles:

  O=C (N (C) [C@@H] (C) C (O[C@H] ([C@@]1 (C) [C@@H] (O1) [C@@H]2C) CC (N (C) C3=C (Cl) C (OC) =CC (C/C (C) =C/C=C/[C@@H] (OC) [C@]4 (O) NC (O[C@H]2C4) =O) =C3) =O) =O) CCNC

• Molecular Formula:

  C36H51ClN4O10

• Molecular Weight:

  735.26

• References & Citations:

  [1]Blanc V, et al. SAR3419: an anti-CD19-Maytansinoid Immunoconjugate for the treatment of B-cell malignancies. Clin Cancer Res. 2011 Oct 15;17 (20) :6448-58. |[2]Andreev Julian, et al. Bispecific antigen binding molecules that bind HER2, and methods of use thereof: World Intellectual Property Organization, WO2021174113. 2021-09-02.

• Shipping Conditions:

  Room Temperature

• Storage Conditions:

  -20°C, 3 years; 4°C, 2 years (Powder)

• Scientific Category:

  ADC Related

• Clinical Information:

  No Development Reported

• CAS Number:

  1628543-40-7