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Maytansinol

CAT: 0804-HY-19474-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-19474-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Maytansinol (Ansamitocin P-0) is a derivative of Maytansine. Maytansinol can inhibit tubulin polymerization and induce apoptosis. Maytansinol has antitumor activity. Maytansinol can be used in cancer drug research[1][2].
CAS Number
57103-68-1
Product Name Alternative
Ansamitocin P-0
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
ADC Payload; Apoptosis; Microtubule/Tubulin
Type
Natural Products
Related Pathways
Antibody-drug Conjugate/ADC Related; Apoptosis; Cell Cycle/DNA Damage; Cytoskeleton
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/Maytansinol.html
Purity
99.84
Solubility
DMSO : ≥ 35 mg/mL
Smiles
C[C@]1([C@H](CC(N(C(C=C2C=C3OC)=C3Cl)C)=O)O)[C@H]([C@@H]([C@](OC4=O)([H])C[C@]([C@](/C=C/C=C(C)/C2)([H])OC)(N4)O)C)O1
Molecular Formula
C28H37ClN2O8
Molecular Weight
565.06
Precautions
H302, H315, H319, H335
References & Citations
[1]Zafar S, et al. New insights into the anticancer therapeutic potential of maytansine and its derivatives. Biomed Pharmacother. 2023 Sep;165:115039.|[2]Edwards A, et al. Combinatorial effect of maytansinol and radiation in Drosophila and human cancer cells. Dis Model Mech. 2011 Jul;4 (4) :496-503.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Natural Products
Clinical Information
No Development Reported

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