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PKR-IN-C16

CAT: 0804-HY-13977A-01Size: 1 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-13977A-01Size:1 mg
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Description
PKR-IN-C16 (Compound C16) is a specific double-stranded RNA-dependent protein kinase (PKR) inhibitor. PKR-IN-C16 shows promising neuroprotective properties and can rescue acute brain lesions[1].
CAS Number
608512-97-6
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
Apoptosis
Type
Reference compound
Related Pathways
Apoptosis
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/pkr-in-c16.html
Purity
99.70
Solubility
DMSO : 10 mg/mL (ultrasonic; warming; heat to 60°C)
Smiles
O=C1/C(C2=C(SC=N3)C3=CC=C2N1)=C\C4=CN=CN4
Molecular Formula
C13H8N4OS
Molecular Weight
268.29
Precautions
H302, H315, H319, H335
References & Citations
[1]Tronel C, et al. The specific PKR inhibitor C16 prevents apoptosis and IL-1β production in an acute excitotoxic rat model with a neuroinflammatory component. Neurochem Int. 2014 Jan;64:73-83.|[2]Page G, et al. Activated double-stranded RNA-dependent protein kinase and neuronal death in models of Alzheimer's disease. Neuroscience. 2006;139 (4) :1343-54.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C, 3 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported

Chemical Information

Imidazolo-oxindole PKR inhibitor C16

C16 is pKR Inhibitor.

CAS Number608512-97-6
PubChem CID6490494
IUPAC Name(8Z)-8-(1H-imidazol-5-ylmethylidene)-6H-pyrrolo[2,3-g][1,3]benzothiazol-7-one
Molecular FormulaC13H8N4OS
Molecular Weight268.30
XLogP1.5
Topological Polar Surface Area98.9
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count4
Rotatable Bond Count1
Heavy Atom Count19
Formal Charge0
Complexity427
SMILES
C1=CC2=C(C\3=C1NC(=O)/C3=C\C4=CN=CN4)SC=N2
InChI
InChI=1S/C13H8N4OS/c18-13-8(3-7-4-14-5-15-7)11-9(17-13)1-2-10-12(11)19-6-16-10/h1-6H,(H,14,15)(H,17,18)/b8-3-
InChIKey
VFBGXTUGODTSPK-BAQGIRSFSA-N
Chemical Structure
2D Structure
2D structure of Imidazolo-oxindole PKR inhibitor C16
CAS: 608512-97-6
CID: 6490494
Formula: C13H8N4OS
MW: 268.30
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight268.30
XLogP31.5
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count4
Rotatable Bond Count1
Exact Mass268.04188206
Monoisotopic Mass268.04188206
Topological Polar Surface Area98.9 Ų
Heavy Atom Count19
Formal Charge0
Complexity427
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count1
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

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