(D-Pro2,D-Trp6,8,Nle10)-Neurokinin B

(D-Pro2,D-Trp6,8,Nle10)-Neurokinin B

• CAS Number: 109212-72-8
• UNSPSC Description: (D-Pro2,D-Trp6,8,Nle10)-Neurokinin B is a competitive antagonist of Neurokinin B (Neurokinin Receptor) with a pA2 of 5.5. (D-Pro2,D-Trp6,8,Nle10)-Neurokinin B shows no influence on Substance P or Neurokinin A[1].
• Target Antigen: Neurokinin Receptor
• Type: Peptides
• Related Pathways: GPCR/G Protein;Neuronal Signaling
• Applications: Neuroscience-Neuromodulation
• Field of Research: Neurological Disease
• Assay Protocol: https://www.medchemexpress.com/d-pro2-d-trp6-8-nle10-neurokinin-b.html
• Solubility: 10 mM in DMSO
• Smiles: O=C([C@@H]1N(CCC1)C([C@@H](N)CC(O)=O)=O)N[C@@H](CC2=CN=CN2)C(N[C@@H](CC(O)=O)C(N[C@@H](CC3=CC=CC=C3)C(N[C@@H](C(N[C@@H](C(C)C)C(N[C@@H](C(N[C@@H](CC(C)C)C(N[C@H](C(N)=O)CCCC)=O)=O)CC4=CNC5=CC=CC=C45)=O)=O)CC6=CNC7=CC=CC=C67)=O)=O)=O
• Molecular Weight: 1326.50
• References & Citations: [1]H I Jacoby, et al. Differentiation of multiple neurokinin receptors in the guinea pig ileum. Life Sci. 1986 Nov 24;39(21):1995-2003. |[2]C W Murray, et al. Neurokinin-induced salivation in the anesthetized rat: a three receptor hypothesis. J Pharmacol Exp Ther. 1987 Aug;242(2):500-6.
• Shipping Conditions: Room temperature
• Clinical Information: No Development Reported