Anti-Hu LOX1 APC

Anti-Hu LOX1 APC

• Background: LOX1, a 31 kDa type II transmembrane protein, is a C-type lectin, functioning as a scavenger receptor for e.g. oxidized low density lipoprotein, apoptotic heat shock proteins, or CRP. It is expressed by macrophages, fibroblasts, platelets, endothelial cells, and smooth muscle cells, and its defects can lead to atherosclerosis. Its expression is enhanced under inflammatory conditions. Multiple splicing variants have been identified.
• Specifications: The mouse monoclonal antibody 15C4 recognizes an extracellular epitope of LOX1, a C-type lectin transmembrane protein.
• CAS Number: 9007-83-4
• Certification: RUO
• Host: Mouse
• Species Reactivity: Human
• Immunogen: fusion protein of human LOX1 ectodomain and of human IgG Fc
• Target Antigen: LOX1
• Isotype: IgG2a κ
• Clone: 15C4
• Applications: Flow cytometry: The reagent is designed for analysis of human blood cells using 10 μl reagent / 100 μl of whole blood or 106 cells in a suspension. The content of a vial (1 mL) is sufficient for 100 tests.
• Validated Applications: FC
• Format: APC
• Buffer: Stabilizing phosphate buffered saline (PBS), pH 7.4, 15 mM sodium azide
• References & Citations: *Duluc D, Banchereau R, Gannevat J, Thompson-Snipes L, Blanck JP, Zurawski S, Zurawski G, Hong S, Urgell JR, Pascual V, Baldwin N, Stecher J, Carley M, Boreham M, Oh S: Transcriptional fingerprints of antigen-presenting cell subsets in the human vaginal mucosa and skin reflect tissue-specific immune microenvironments. Genome Med. 2014 Nov 256(11):98., URL: https://pubmed.ncbi.nlm.nih.gov/25520755/,*Cassetta L, Bruderek K, Skrzeczynska J, Osiecka O, Hu X, Rundgren IM, Lin A, Santegoets K, Horzum U, Godinho-Santos A, Zelinsky G, Garcia-Tellez T, Bjelica S, Taciak B, Kittang AO, Höing B, Lang S, Dixon M, Müller V, Utíkal JS, Karakoç D, Yilmaz KB, Górka E, Bodnár L, Anastasiou OE, Bourgeois C, Baďura R, Kapinska-Mrowiecka M, Gotic M, Laan MT, Kers-Rebel E, Król M, Santibañez JF, Müller M, Dittmer U, de Sousa AE, Esendağli G, Adema G, Loré K, Ersvær E, Umansky V, Pollard JW, Cichy J, Brandau S: Differential expansion of circulating human MDSC subsets in patients with cancer, infection and inflammation. J Immunother Cancer. 2020 Sep8(2):e001223., URL: https://pubmed.ncbi.nlm.nih.gov/32907925/,*Joo H, Li D, Dullaers M, Kim TW, Duluc D, Upchurch K, Xue Y, Zurawski S, Le Grand R, Liu YJ, Kuroda M, Zurawski G, Oh S: C-type lectin-like receptor LOX-1 promotes dendritic cell-mediated class-switched B cell responses. Immunity 2014 Oct 1641(4):592-604., URL: https://pubmed.ncbi.nlm.nih.gov/25308333/,*Bayik D, Zhou Y, Park C, Hong C, Vail D, Silver DJ, Lauko A, Roversi G, Watson DC, Lo A, Alban TJ, McGraw M, Sorensen M, Grabowski MM, Otvos B, Vogelbaum MA, Horbinski C, Kristensen BW, Khalil AM, Hwang TH, Ahluwalia MS, Cheng F, Lathia JD: Myeloid-derived suppressor cell subsets drive glioblastoma growth in a sex-specific manner. Cancer Discov. 2020 Aug10(8):1210-1225., URL: https://pubmed.ncbi.nlm.nih.gov/32300059/,*Li D, Romain G, Flamar AL, Duluc D, Dullaers M, Li XH, Zurawski S, Bosquet N, Palucka AK, Le Grand R, O'Garra A, Zurawski G, Banchereau J, Oh S: Targeting self- and foreign antigens to dendritic cells via DC-ASGPR generates IL-10-producing suppressive CD4+ T cells. J Exp Med. 2012 Jan 16209(1):109-21., URL: https://pubmed.ncbi.nlm.nih.gov/22213806/,
• Storage Conditions: Store at 2-8°C. Protect from prolonged exposure to light. Do not freeze.