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AS-041164

CAT: 0804-HY-118521-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-118521-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
AS-041164 is a potent, selective and orally active PI3Kγ isoform inhibitor with an IC50 of 70 nM. AS-041164 shows less activity against PI3Kα, PI3Kβ, and PI3Kδ (IC50s of 240 nM, 1.45 μM, and 1.70 μM, respectively) . AS-041164 has anti-inflammatory effects[1].
CAS Number
6318-41-8
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
PI3K
Type
Reference compound
Related Pathways
PI3K/Akt/mTOR
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/as-041164.html
Purity
99.02
Solubility
DMSO : 125 mg/mL (ultrasonic)
Smiles
O=C(N1)/C(SC1=O)=C/C2=CC=C3C(OCO3)=C2
Molecular Formula
C11H7NO4S
Molecular Weight
249.24
Precautions
H302, H315, H319, H335
References & Citations
[1]Chiara Ferrandi, et al. Phosphoinositide 3-kinase gamma inhibition plays a crucial role in early steps of inflammation by blocking neutrophil recruitment. J Pharmacol Exp Ther. 2007 Sep;322 (3) :923-30.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, protect from light)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
PI3Kα; PI3Kβ; PI3Kγ; PI3Kδ

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