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Cortistatin-8

CAT: 0804-HY-P1139-01Size: 1 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-P1139-01Size:1 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Cortistatin-8 (CST-8; PCFWKTCK), a neuropeptide, is a GHS-R1a antagonist by counteracting the response of ghrelin on gastric acid secretion. Cortistatin-8 can modulate GH release from somatotroph cells. Cortistatin-8 is a synthetic CST-analogue devoid of any binding affinity to SST-R but capable to bind the GHS-R1a. Cortistatin-8 can exert antagonistic effects on ghrelin actions either in vitro or in vivo in animals[1].
CAS Number
485803-62-1
Product Name Alternative
PCFWKTCK
UNSPSC
12352209
Target
GHSR
Type
Reference compound
Related Pathways
GPCR/G Protein
Applications
Metabolism-protein/nucleotide metabolism
Field of Research
Metabolic Disease
Assay Protocol
https://www.medchemexpress.com/cortistatin-8.html
Purity
98.86
Smiles
O=C(N[C@@H]1CC2=CNC3=CC=CC=C23)[C@H](CC4=CC=CC=C4)NC([C@@]([H])(NC([C@@H]5CCCN5)=O)CSSC[C@H](NC([C@@]([H])(NC([C@@]([H])(NC1=O)CCCCN)=O)[C@@H](C)O)=O)C(N[C@@H](CCCCN)C(N)=O)=O)=O
Molecular Formula
C47H68N12O9S2
Molecular Weight
1009.25
References & Citations
[1]F Prodam, et al. Cortistatin-8, a synthetic cortistatin-derived ghrelin receptor ligand, does not modify the endocrine responses to acylated ghrelin or hexarelin in humans. Neuropeptides. 2008 Feb;42 (1) :89-93.
Shipping Conditions
Blue Ice
Storage Conditions
-80°C, 2 years; -20°C, 1 year (Powder, sealed storage, away from moisture)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
GHSR1a

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