Cortistatin-8

• Description :

  Cortistatin-8 (CST-8; PCFWKTCK), a neuropeptide, is a GHS-R1a antagonist by counteracting the response of ghrelin on gastric acid secretion. Cortistatin-8 can modulate GH release from somatotroph cells. Cortistatin-8 is a synthetic CST-analogue devoid of any binding affinity to SST-R but capable to bind the GHS-R1a. Cortistatin-8 can exert antagonistic effects on ghrelin actions either in vitro or in vivo in animals[1].

• Product Name Alternative :

  PCFWKTCK

• UNSPSC :

  12352209

• Target :

  GHSR

• Type :

  Reference compound

• Related Pathways :

  GPCR/G Protein

• Applications :

  Metabolism-protein/nucleotide metabolism

• Field of Research :

  Metabolic Disease

• Assay Protocol :

  https://www.medchemexpress.com/cortistatin-8.html

• Purity :

  98.86

• Smiles :

  O=C(N[C@@H]1CC2=CNC3=CC=CC=C23)[C@H](CC4=CC=CC=C4)NC([C@@]([H])(NC([C@@H]5CCCN5)=O)CSSC[C@H](NC([C@@]([H])(NC([C@@]([H])(NC1=O)CCCCN)=O)[C@@H](C)O)=O)C(N[C@@H](CCCCN)C(N)=O)=O)=O

• Molecular Formula :

  C47H68N12O9S2

• Molecular Weight :

  1009.25

• References & Citations :

  [1]F Prodam, et al. Cortistatin-8, a synthetic cortistatin-derived ghrelin receptor ligand, does not modify the endocrine responses to acylated ghrelin or hexarelin in humans. Neuropeptides. 2008 Feb;42 (1) :89-93.

• Shipping Conditions :

  Blue Ice

• Storage Conditions :

  -80°C, 2 years; -20°C, 1 year (Powder, sealed storage, away from moisture)

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported

• Isoform :

  GHSR1a

• CAS Number :

  [485803-62-1]