3,4,5-Trimethoxycinnamic acid

3,4,5-Trimethoxycinnamic acid

• CAS Number: 90-50-6
• UNSPSC Description: 3,4,5-Trimethoxycinnamic acid is a phenylpropanoid isolated from the roots of Polygala tenuifolia WILLD, with anti-stress effect, prolonging the sleeping time in animals[1][2]. 3,4,5-Trimethoxycinnamic acid increases expression of GAD65 and γ-subunit of GABAA receptor, but shows no effect on the amounts of α-, β-subunits[2].
• Target Antigen: Endogenous Metabolite; GABA Receptor
• Type: Natural Products
• Related Pathways: Membrane Transporter/Ion Channel;Metabolic Enzyme/Protease;Neuronal Signaling
• Applications: Neuroscience-Neuromodulation
• Field of Research: Neurological Disease
• Assay Protocol: https://www.medchemexpress.com/3,4,5-Trimethoxycinnamic_acid.html
• Purity: 99.86
• Solubility: DMSO : 100 mg/mL (ultrasonic)
• Smiles: COC1=C(OC)C(OC)=CC(/C=C/C(O)=O)=C1
• Molecular Weight: 238.239
• References & Citations: [1]Kawashima K, et al. Anti-stress effects of 3,4,5-trimethoxycinnamic acid, an active constituent of roots of Polygala tenuifolia (Onji). Biol Pharm Bull. 2004 Aug;27(8):1317-9.|[2]Lee CI, et al. 3,4,5-Trimethoxycinnamic acid (TMCA), one of the constituents of Polygalae Radix enhances pentobarbital-induced sleeping behaviors via GABAAergic systems in mice. Arch Pharm Res. 2013 Oct;36(10):1244-51.
• Shipping Conditions: Room Temperature
• Storage Conditions: -20°C, 3 years; 4°C, 2 years (Powder)
• Clinical Information: No Development Reported