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(E) -3,4,5-Trimethoxycinnamic acid

CAT: 0804-HY-W050162-01Size: 50 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-W050162-01Size:50 mg
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Description
(E) -3,4,5-Trimethoxycinnamic acid (TMCA) is a cinnamic acid substituted by multi-methoxy groups. (E) -3,4,5-Trimethoxycinnamic acid is an orally active and potent GABAA/BZ receptor agonist. (E) -3,4,5-Trimethoxycinnamic exhibits favourable binding affinity to 5-HT2C and 5-HT1A receptor, with IC50 values of 2.5 and 7.6 μM, respectively. (E) -3,4,5-Trimethoxycinnamic acid shows anticonvulsant and sedative activity. (E) -3,4,5-Trimethoxycinnamic acid can be used for the research of insomnia, headache and epilepsy[1][2][3].
CAS Number
20329-98-0
Product Name Alternative
TMCA
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
5-HT Receptor; GABA Receptor
Type
Reference compound
Related Pathways
GPCR/G Protein; Membrane Transporter/Ion Channel; Neuronal Signaling
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/e-3-4-5-trimethoxycinnamic-acid.html
Purity
99.97
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
O=C(O)/C=C/C1=CC(OC)=C(OC)C(OC)=C1
Molecular Formula
C12H14O5
Molecular Weight
238.24
Precautions
H302, H315, H319, H335
References & Citations
[1]Zhao Z, et al. Research progress in the biological activities of 3,4,5-trimethoxycinnamic acid (TMCA) derivatives. Eur J Med Chem. 2019 Jul 1;173:213-227.|[2]Chen CY, et al. 3,4,5-Trimethoxycinnamic acid, one of the constituents of Polygalae Radix exerts anti-seizure effects by modulating GABAAergic systems in mice. J Pharmacol Sci. 2016 May;131 (1) :1-5. |[3]Lee CI, et al. 3,4,5-Trimethoxycinnamic acid (TMCA), one of the constituents of Polygalae Radix enhances pentobarbital-induced sleeping behaviors via GABAAergic systems in mice. Arch Pharm Res. 2013 Oct;36 (10) :1244-51.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
5-HT1 Receptor;5-HT2 Receptor; mLAG-3; MUC2; MUC3; α-1 microglobulin

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