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Diethyl fumarate

CAT: 0804-HY-W010056-01Size: 500 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-W010056-01Size:500 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Diethyl fumarate is a decomposition product of Malathion 9 (a pesticide) and reactant in the Diels-Alder reaction. Diethyl fumarate is a reputed skin irritant. Diethyl fumarate can causes non-immunologic contact urticaria on skin. Diethyl fumarate and Curcumin hybridize to exert neuroprotective effects[1][2][3][4].
CAS Number
623-91-6
UNSPSC
12352211
Hazard Statement
H227, H302, H401
Target
Others
Type
Natural Products
Related Pathways
Others
Applications
Metabolism-protein/nucleotide metabolism
Field of Research
Inflammation/Immunology; Neurological Disease
Assay Protocol
https://www.medchemexpress.com/diethyl-fumarate.html
Purity
99.40
Solubility
DMSO : 140 mg/mL (ultrasonic) |H2O : 3 mg/mL (ultrasonic)
Smiles
O=C(OCC)/C=C/C(OCC)=O
Molecular Formula
C8H12O4
Molecular Weight
172.18
Precautions
H227, H302, H401
References & Citations
[1]Jr FA, et, al. Gas chromatographic determination of diethyl fumarate in malathion extracts and preparations used for control of body lice. J Econ Entomol. 1968 Apr;61 (2) :457-9.|[2]Lahti A, et, al. Contact urticaria from diethyl fumarate. Contact Dermatitis. 1985 Mar;12 (3) :139-40.|[3]Di Martino RMC, et al. Novel Curcumin-Diethyl Fumarate Hybrid as a Dualistic GSK-3β Inhibitor/Nrf2 Inducer for the Treatment of Parkinson's Disease. ACS Chem Neurosci. 2020 Sep 2;11 (17) :2728-2740. |[4]Silvestri M G, et al. A kinetic study of the Diels-Alder reaction: An experiment illustrating simple second-order reaction kinetics. Journal of Chemical Education, 1989, 66 (8) : 690.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Natural Products
Clinical Information
No Development Reported

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