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GQN-B37-E

CAT: 0804-HY-161732Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-161732Size:1 Each
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Description
GQN-B37-E is a potent selective binder and inhibitor of MCL-1. GQN-B37-E binds to the BH3-domain-binding pocket in MCL-1. GQN-B37-E exhibits binding affinity for MCL-1 at the submicromolar range (Ki = 0.6 μM) without apparent binding to BCL-2 or BCL-XL[1].
CAS Number
2982663-28-3
UNSPSC
12352005
Target
Bcl-2 Family
Type
Reference compound
Related Pathways
Apoptosis
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/gqn-b37-e.html
Smiles
O=C(O)[C@H](CC1=CNC2=CC=CC=C12)NC(/C=C/C3=CN(C4=CC=CC(Cl)=C4)N=C3C5=CC=C(O)C=C5)=O
Molecular Formula
C29H23ClN4O4
Molecular Weight
526.97
References & Citations
[1]Gong Q, et al. Discovery of Phenylpyrazole Derivatives as a New Class of Selective Inhibitors of MCL-1 with Antitumor Activity. ACS Omega. 2024 Jun 13;9 (25) :27369-27396.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
Mcl-1

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