Pipamperone (Standard)

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Description

Pipamperone (Standard) is the analytical standard of Pipamperone. This product is intended for research and analytical applications. Pipamperone (Floropipamide) is a butyrophenone derivative and high-affinity antagonist of 5-HT2A receptor (pKi=8.2) and D4 receptor (pKi=8.0). Pipamperone is also a low-affinity antagonist of D2 receptor (pKi=6.7). Pipamperone affects neurotransmitter functions and exerts antipsychotic activity. Pipamperone is used in the research of mental disorders such as autism-related behavioral disorders and Alzheimer's disease[1][2][3][4].

CAS Number

1893-33-0

Product Name Alternative

Floropipamide (Standard) ; McN-JR 3345 (Standard) ; R 3345 (Standard)

UNSPSC

12352005

Target

5-HT Receptor; Dopamine Receptor; Reference Standards

Type

Reference Standards

Related Pathways

GPCR/G Protein; Neuronal Signaling; Others

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/pipamperone-standard.html

Smiles

O=C(C1(N2CCCCC2)CCN(CCCC(C3=CC=C(F)C=C3)=O)CC1)N

Molecular Formula

C21H30FN3O2

Molecular Weight

375.48

References & Citations

[1]Erik Buntinx, MD, et al. Selective Serotonergic Properties of Low-Dose Pipamperone May Enhance Antidepressant Effect: Preclinical Evidence.

Shipping Conditions

Room temperature

Scientific Category

Reference Standards

Isoform

5-HT2 Receptor

Chemical Information

Pipamperone

Pipamperone is a member of the class of bipiperidines that is 1,4'-bipiperidine which is substituted at the 1' and 4' positions by 4-(p-fluorophenyl)-4-oxobutyl and carboxamide groups, respectively. A first generation antipsychotic, its properties are generally similar to those of haloperidol. It has a role as a serotonergic antagonist, a dopaminergic antagonist and a first generation antipsychotic. It is a monocarboxylic acid amide, an organofluorine compound, a member of bipiperidines, a tertiary amino compound and an aromatic ketone. It is a conjugate base of a pipamperone(2+).

CAS Number	1893-33-0
PubChem CID	4830
IUPAC Name	1-[4-(4-fluorophenyl)-4-oxobutyl]-4-piperidin-1-ylpiperidine-4-carboxamide
Molecular Formula	C21H30FN3O2
Molecular Weight	375.5
XLogP	2
Topological Polar Surface Area	66.6
Hydrogen Bond Donor Count	1
Hydrogen Bond Acceptor Count	5
Rotatable Bond Count	7
Heavy Atom Count	27
Formal Charge	0
Complexity	506

SMILES

C1CCN(CC1)C2(CCN(CC2)CCCC(=O)C3=CC=C(C=C3)F)C(=O)N

InChI

InChI=1S/C21H30FN3O2/c22-18-8-6-17(7-9-18)19(26)5-4-12-24-15-10-21(11-16-24,20(23)27)25-13-2-1-3-14-25/h6-9H,1-5,10-16H2,(H2,23,27)

InChIKey

AXKPFOAXAHJUAG-UHFFFAOYSA-N

Chemical Structure

2D Structure

CAS: 1893-33-0

CID: 4830

Formula: C21H30FN3O2

MW: 375.5

Interactive 3D Structure

Loading 3D structure...

View on PubChem Raw 3D data

Computed Properties

Property	Value
Molecular Weight	375.5
XLogP3	2
Hydrogen Bond Donor Count	1
Hydrogen Bond Acceptor Count	5
Rotatable Bond Count	7
Exact Mass	375.23220537
Monoisotopic Mass	375.23220537
Topological Polar Surface Area	66.6 Å²
Heavy Atom Count	27
Formal Charge	0
Complexity	506
Isotope Atom Count	0
Defined Atom Stereocenter Count	0
Undefined Atom Stereocenter Count	0
Defined Bond Stereocenter Count	0
Undefined Bond Stereocenter Count	0
Covalently-Bonded Unit Count	1
Compound Is Canonicalized	Yes

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Alternative Products

Catalog	Name
BA5037-1	Pipamperone
TRC-P475200-100MG	Pipamperone Dihydrochloride
MBS5778099	Pipamperone HCl
A12621-5	Pipamperone 5mg
A12621-1	Pipamperone 1mg
A12621-100	Pipamperone 100mg
A12621-50	Pipamperone 50mg
A12621-25	Pipamperone 25mg
A12621-10	Pipamperone 10mg
A12621-2	Pipamperone 2mg

Pipamperone (Standard)

Chemical Information

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