Pipamperone

• Description :

  Pipamperone (Floropipamide) is a butyrophenone derivative and high-affinity antagonist of 5-HT2A receptor (pKi=8.2) and D4 receptor (pKi=8.0) . Pipamperone is also a low-affinity antagonist of D2 receptor (pKi=6.7) . Pipamperone affects neurotransmitter functions and exerts antipsychotic activity. Pipamperone is used in the research of mental disorders such as autism-related behavioral disorders and Alzheimer's disease[1][2][3][4].

• Product Name Alternative :

  Floropipamide; McN-JR 3345; R 3345

• UNSPSC :

  12352005

• Hazard Statement :

  H301, H411

• Target :

  5-HT Receptor; Dopamine Receptor

• Type :

  Reference compound

• Related Pathways :

  GPCR/G Protein; Neuronal Signaling

• Applications :

  Neuroscience-Neuromodulation

• Field of Research :

  Neurological Disease

• Assay Protocol :

  https://www.medchemexpress.com/pipamperone.html

• Concentration :

  10mM

• Purity :

  99.89

• Solubility :

  0.1 M HCl : 25 mg/mL (ultrasonic) |DMSO : 100 mg/mL (ultrasonic)

• Smiles :

  O=C(C1(N2CCCCC2)CCN(CCCC(C3=CC=C(F)C=C3)=O)CC1)N

• Molecular Formula :

  C21H30FN3O2

• Molecular Weight :

  375.48

• Precautions :

  H301, H411

• References & Citations :

  [1]Erik Buntinx, MD, et al. Selective Serotonergic Properties of Low-Dose Pipamperone May Enhance Antidepressant Effect: Preclinical Evidence.|[2]Oekelen DV, et al. Different regulation of rat 5-HT (2A) and rat 5-HT (2C) receptors in NIH 3T3 cells upon exposure to 5-HT and pipamperone. Eur J Pharmacol. 2001 Aug 3;425 (1) :21-32. |[3]Petrosino B, et al. The treatment of autism with pipamperone: a case report. European Psychiatry, 2016, 33 (S1) : S549-S549. |[4]Kamp D, et al. Hypothermia in a patient with Alzheimer's disease receiving a combination therapy with risperidone and pipamperone. Ther Adv Psychopharmacol. 2016 Feb;6 (1) :55-7.

• Shipping Conditions :

  Room Temperature

• Storage Conditions :

  4°C (Powder, protect from light)

• Scientific Category :

  Reference compound1

• Clinical Information :

  Launched

• Isoform :

  5-HT2 Receptor; D2 Receptor; D4 Receptor; mLAG-3; α-1 microglobulin

• CAS Number :

  [1893-33-0]