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Pipamperone

CAT: 0804-HY-100703-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-100703-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Pipamperone (Floropipamide) is a butyrophenone derivative and high-affinity antagonist of 5-HT2A receptor (pKi=8.2) and D4 receptor (pKi=8.0) . Pipamperone is also a low-affinity antagonist of D2 receptor (pKi=6.7) . Pipamperone affects neurotransmitter functions and exerts antipsychotic activity. Pipamperone is used in the research of mental disorders such as autism-related behavioral disorders and Alzheimer's disease[1][2][3][4].
CAS Number
1893-33-0
Product Name Alternative
Floropipamide; McN-JR 3345; R 3345
UNSPSC
12352005
Hazard Statement
H301, H411
Target
5-HT Receptor; Dopamine Receptor
Type
Reference compound
Related Pathways
GPCR/G Protein; Neuronal Signaling
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/pipamperone.html
Concentration
10mM
Purity
99.89
Solubility
0.1 M HCl : 25 mg/mL (ultrasonic) |DMSO : 100 mg/mL (ultrasonic)
Smiles
O=C(C1(N2CCCCC2)CCN(CCCC(C3=CC=C(F)C=C3)=O)CC1)N
Molecular Formula
C21H30FN3O2
Molecular Weight
375.48
Precautions
H301, H411
References & Citations
[1]Erik Buntinx, MD, et al. Selective Serotonergic Properties of Low-Dose Pipamperone May Enhance Antidepressant Effect: Preclinical Evidence.|[2]Oekelen DV, et al. Different regulation of rat 5-HT (2A) and rat 5-HT (2C) receptors in NIH 3T3 cells upon exposure to 5-HT and pipamperone. Eur J Pharmacol. 2001 Aug 3;425 (1) :21-32. |[3]Petrosino B, et al. The treatment of autism with pipamperone: a case report. European Psychiatry, 2016, 33 (S1) : S549-S549. |[4]Kamp D, et al. Hypothermia in a patient with Alzheimer's disease receiving a combination therapy with risperidone and pipamperone. Ther Adv Psychopharmacol. 2016 Feb;6 (1) :55-7.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, protect from light)
Scientific Category
Reference compound1
Clinical Information
Launched
Isoform
5-HT2 Receptor; D2 Receptor; D4 Receptor; mLAG-3; α-1 microglobulin

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